Evidence map›Paper›PMID 32695958›Full record

ArticleGeneral psychiatry2020

Amplitude of low-frequency fluctuations on Alzheimer's disease with depression: evidence from resting-state fMRI.

Yuzhu Mu, Yumei Li, Qi Zhang, Zhongxiang Ding, Mei Wang, Xingguang Luo, Xiaoyun Guo, Maosheng Xu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in General psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Yuzhu MuDepartment of Ultrasound, the First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China.
Yumei LiDepartment of Radiology, Zhejiang Provincial People's Hospital, Hospital of Hangzhou Medical College, Hangzhou, China.
Qi ZhangDepartment of Radiology, the First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China.
Zhongxiang DingTranslational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Mei WangTranslational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xingguang LuoDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Xiaoyun GuoShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Maosheng XuDepartment of Radiology, the First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China.
Zhejiang Chinese Medical University · CNHangzhou First People's Hospital · CNShanghai Jiao Tong University · CNYale University · USZhejiang Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of Alzheimer's disease (AD) comorbid with depression is common. However, the mechanisms of AD with depression remain unclear.

aimsTo investigate the regional alterations of brain activity of AD with depression in resting-state functional magnetic resonance imaging (rs-fMRI).

methods154 patients with AD who met the inclusion criteria were recruited from the Zhejiang Provincial People's Hospital from October 2014 to October 2016. According to whether the core symptoms of depression were present, patients were divided into two groups, 22 patients with AD with depression (AD-D) and 52 patients with AD without depression (AD-nD). The amplitude of low frequency fluctuations (ALFF) was compared between two groups by performing independent-samples

resultsCompared with the AD-D group, increased ALFF values in the bilateral superior frontal gyrus, left middle frontal gyrus and left inferior frontal gyrus were observed in the AD-nD group. The brain activity in the AD-nD group in the bilateral superior frontal gyrus, left middle frontal gyrus and the left inferior frontal gyrus was higher than the AD-D group.

conclusionsResting-state brain functional alterations may be closely bound up with the pathophysiologic features of patients with AD with depressive symptoms.

Indexed as

Alzheimer’s diseaseamplitude of low frequency fluctuationsdepressionresting-state functional magnetic resonance imaging

Identifiers

PMID32695958
PMCPMC7351268
OpenAlexW3041966779

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.