Evidence map›Paper›PMID 32695957›Full record

ArticleCurrent developments in nutrition2020

Variation of Serum Lycopene in Response to 100% Watermelon Juice: An Exploratory Analysis of Genetic Variants in a Randomized Controlled Crossover Study.

Kristi M Crowe-White, Venkata S Voruganti, Valentina Talevi, Tanja Dudenbostel, Vinoth A Nagabooshanam, Julie L Locher, Amy C Ellis

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current developments in nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03626168 (Bioactive Compounds in Watermelon Modulating Oxidative Stress and Inflammation in Elders), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03626168 nacompletednot on this map

Bioactive Compounds in Watermelon Modulating Oxidative Stress and Inflammation in Elders: The MOXIE Study

TypeinterventionalSponsorUniversity of Alabama, TuscaloosaRan2016 to 2018Enrolled21ConditionsArterial Stiffness, InflammationArms100% watermelon juice, Placebo beverage
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kristi M Crowe-WhiteDepartment of Human Nutrition, University of Alabama, Tuscaloosa, AL, USA.ORCID 0000-0003-2497-4582
Venkata S VorugantiDepartment of Nutrition and Nutrition Research Institute, University of North Carolina-Chapel Hill, Kannapolis, NC, USA.
Valentina TaleviDepartment of Nutrition and Nutrition Research Institute, University of North Carolina-Chapel Hill, Kannapolis, NC, USA.
Tanja DudenbostelCardiovascular Disease, Vascular Biology & Hypertension, University of Alabama at Birmingham, Birmingham, AL, USA.
Vinoth A NagabooshanamNutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Julie L LocherDivision of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham, Birmingham, AL, USA.
Amy C EllisDepartment of Human Nutrition, University of Alabama, Tuscaloosa, AL, USA.
University of Alabama at Birmingham · USDavid H. Murdock Research Institute · USUniversity of Alabama · US

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
Translational Nutrition and Aging Research Academic Career Leadership AwardK07AG043588 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LOCHER, JULIE L. · 2012 to 2016
$583k
NIA NIH HHS K07 AG043588NIDDK NIH HHS P30 DK056350
6 · The paper itself

Abstract

backgroundWatermelon, a rich source of lycopene, has garnered attention for cardioprotective effects including cholesterol reduction and promotion of redox balance. It is unknown whether 100% watermelon juice may represent a food-first approach to confer cardioprotective benefits of lycopene.

objectivesThis study examined influences of 100% watermelon juice on serum lycopene, lipids, and antioxidant capacity. Secondly, the study explored genetic influences on lycopene metabolism and bioavailability.

methodsA placebo-controlled, randomized, double-blind, crossover trial with postmenopausal women (

resultsSerum lycopene exhibited a significant treatment effect (

conclusionsWatermelon juice supplementation did not result in improvements in serum lipids or antioxidant capacity; however, results support findings in which watermelon juice significantly, yet differentially, increased circulating lycopene. Genetics appears to explain some of the variability. Given that dose has been shown to overcome individual responsiveness to lycopene interventions, future investigations with varying doses of lycopene-rich foods would be strengthened by genotyping so as to establish personalized nutrition recommendations.This trial was registered at clinicaltrials.gov as NCT03626168.

Indexed as

antioxidant capacitycarotenoidscholesterollycopenenutrigenomicspostmenopausal womensingle nucleotide polymorphismswatermelon

Identifiers

PMID32695957
PMCPMC7363307
OpenAlexW3036394559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.