Evidence map›Paper›PMID 32695928›Full record

ArticleAmerican journal of ophthalmology case reports2020

Trichiasis and dry eye syndrome in two patients on novel fibroblast growth factor receptor inhibitor therapies.

Kyle B Vinson, Wesley M Gillette, Catherine F Baston, Alan B Leahey

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. A review on drug-induced dry eye disease.Indian journal of ophthalmology · 2023
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kyle B VinsonUniversity of South Carolina School of Medicine Greenville, 607 Grove Road, Greenville, SC, 29605, USA.
Wesley M GilletteUniversity of South Carolina School of Medicine Greenville, 607 Grove Road, Greenville, SC, 29605, USA.
Catherine F BastonDivision of Ophthalmology, Department of Surgery, Prisma Health - Upstate, 104 Simpson Street, Greenville, SC, 29605, USA.
Alan B LeaheyDivision of Ophthalmology, Department of Surgery, Prisma Health - Upstate, 104 Simpson Street, Greenville, SC, 29605, USA.
Prisma Health · USUniversity of South Carolina · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePresent two patients on two different novel FGFR inhibitors who developed trichiasis with dry eye syndrome. OBSERVATIONS: Two patients developed trichiasis and dry eye following FGFR inhibitor therapy. Treatments included artificial tears, lifitegrast or cyclosporine, and epilation as needed. One patient discontinued treatment with AZD4547 due to the severity of the ocular adverse effects. CONCLUSIONS AND IMPORTANCE: Trichiasis has not yet been reported in patients receiving AZD4547 or INCB054828 treatments and may represent a rare adverse effect of these drugs. Continued research is necessary to determine whether there is a definite link between these FGFR inhibitors and the development of trichiasis.

Indexed as

AZD4547dry eyeFibroblast growth factor receptor (FGFR) inhibitorINCB054828PemigatinibTrichiasis

Identifiers

PMID32695928
PMCPMC7363660
OpenAlexW3042136386

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.