ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Small vessel disease lesion type and brain atrophy: The role of co-occurring amyloid.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- A bibliometric analysis of international publication trends in brain atrophy research (2008-2023).Frontiers in neurology · 2024Pooled it
- Oral microbiota dysbiosis related to the cortical thinning and cognitive impairment in cerebral small vessel disease.Journal of oral microbiology · 2026Article
- Synergistic effect between cortical cerebral microinfarcts and brain atrophy on cognitive decline.Brain : a journal of neurology · 2025Article
- White matter hyperintensities drive propagating grey matter atrophy in cerebral small vessel disease.Brain communications · 2025Article
- Atherosclerosis and Hippocampal Volumes in Older Adults: The Role of Age and Blood Pressure.Journal of the American Heart Association · 2024Article
- Neuroimaging determinants of cognitive impairment in the memory clinic: how important is the vascular burden?Journal of neurology · 2024Article
- Cortical microstructural involvement in cerebral small vessel disease.Cerebral circulation - cognition and behavior · 2024Article
- Fractal dimension of the cortical gray matter outweighs other brain MRI features as a predictor of transition to dementia in patients with mild cognitive impairment and leukoaraiosis.Frontiers in human neuroscience · 2023Article
- Individual prediction and classification of cognitive impairment in patients with white matter lesions based on gray matter volume.Annals of translational medicine · 2022Article
- Small vessel disease lesion type and brain atrophy: The role of co-occurring amyloid.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
introductionIt is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co-occurring Alzheimer's disease pathology affects this relation.
methodsIn 725 memory clinic patients with SVD (mean age 67 ± 8 years, 48% female) we compared brain volumes of those with moderate/severe white matter hyperintensities (WMHs; n = 326), lacunes (n = 132) and cerebral microbleeds (n = 321) to a reference group with mild WMHs (n = 197), also considering cerebrospinal fluid (CSF) amyloid status in a subset of patients (n = 488).
resultsWMHs and lacunes, but not cerebral microbleeds, were associated with smaller gray matter (GM) volumes. In analyses stratified by CSF amyloid status, WMHs and lacunes were associated with smaller total brain and GM volumes only in amyloid-negative patients. SVD-related atrophy was most evident in frontal (cortical) GM, again predominantly in amyloid-negative patients. DISCUSSION: Amyloid status modifies the differential relation between SVD lesion type and brain atrophy in memory clinic patients.
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