ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Reduced cortical thickness in World Trade Center responders with cognitive impairment.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 35 citations in OpenAlex.
- World Trade Center neurotoxicant exposure severity is associated with cortical thinning and regional brain atrophy: a neuroimaging study of general responders at midlife.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Toward multimodal MRI biomarkers of PTSD: functional and structural connectivity signatures in WTC responders.medRxiv : the preprint server for health sciences · 2026Article
- Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Reduced Gray-White Matter Contrast in Chronic Posttraumatic Stress Disorder in World Trade Center Responders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Cognitive Impairment: A Novel Risk Factor for Rapid Kidney Function Decline and Incident CKD in Middle-Aged Adults.Kidney360 · 2025Article
- MRI signature of brain age underlying post-traumatic stress disorder in World Trade Center responders.Translational psychiatry · 2025Article
- Increased Aβ40 in plasma is associated with severity of exposure to airborne pollutants at the World Trade Center: a cross-sectional study of neurological biomarkers.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Prevalence of Mild and Severe Cognitive Impairment in World Trade Center Exposed Fire Department of the City of New York (FDNY) and General Emergency Responders.American journal of industrial medicine · 2025Article
- Exposure duration and cerebral amyloidosis in the olfactory cortex of World Trade Center responders: A positron emission tomography and magnetic resonance imaging study.Journal of Alzheimer's disease : JAD · 2025Article
- Prevalence of Mild and Severe Cognitive Impairment in World Trade Center Exposed Fire Department of the City of New York (FDNY) and General Emergency Responders.medRxiv : the preprint server for health sciences · 2024Article
- Incidence of Dementia Before Age 65 Years Among World Trade Center Attack Responders.JAMA network open · 2024Article
- Behavioral Impairments and Increased Risk of Cortical Atrophy Risk Scores Among World Trade Center Responders.Journal of geriatric psychiatry and neurology · 2024Article
- Functional changes in neural mechanisms underlying post-traumatic stress disorder in World Trade Center responders.Translational psychiatry · 2023Article
- World Trade Center Site Exposure Duration Is Associated with Hippocampal and Cerebral White Matter Neuroinflammation.Molecular neurobiology · 2023Article
- Physical Functional Impairment and the Risk of Incident Mild Cognitive Impairment in an Observational Study of World Trade Center Responders.Neurology. Clinical practice · 2022Article
- Assessment of Alzheimer's Disease Imaging Biomarkers in World Trade Center Responders with Cognitive Impairment at Midlife.World journal of nuclear medicine · 2022Article
- Reduced cerebellar cortical thickness in World Trade Center responders with cognitive impairment.Translational psychiatry · 2022Article
- Cognitive impairment and World Trade Centre-related exposures.Nature reviews. Neurology · 2022Review
- Health effects following exposure to dust from the World Trade Center disaster: An update.Life sciences · 2022Review
- DTI Connectometry Analysis Reveals White Matter Changes in Cognitively Impaired World Trade Center Responders at Midlife.Journal of Alzheimer's disease : JAD · 2022Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
introductionThis study examined cortical thickness (CTX) in World Trade Center (WTC) responders with cognitive impairment (CI).
methodsWTC responders (N = 99) with/without CI, recruited from an epidemiologic study, completed a T1-MPRAGE protocol. CTX was automatically computed in 34 regions of interest. Region-based and surface-based morphometry examined CTX in CI versus unimpaired responders. CTX was automatically computed in 34 regions of interest. Region-based measures were also compared to published norms.
resultsParticipants were 55.8 (SD = 0.52) years old; 48 had CI. Compared to unimpaired responders, global mean CTX was reduced in CI and across 21/34 cortical subregions. Surface-based analyses revealed reduced CTX across frontal, temporal, and parietal lobes when adjusting for multiple comparisons. Both CI and unimpaired WTC groups had reduced CTX in the entorhinal and temporal cortices compared to published normative data. DISCUSSION: Results from the first structural magnetic resonance imaging study in WTC responders identified reduced CTX consistent with a neurodegenerative disease of unknown etiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.