ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Collective effects of age, sex, genotype, and cognitive status on fitness outcomes.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- Rising energetic cost of walking predicts cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes.Neurobiology of aging · 2023Article
- Examining Relationships between Cognitive Flexibility, Exercise Perceptions, and Cardiovascular Disease Risk Factors.European journal of investigation in health, psychology and education · 2023Article
- Increased Functional Connectivity of the Precuneus in Individuals with a Family History of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Editorial: Systemic implications of Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Energetic Cost of Walking and Brain Atrophy in Mid-to-Late Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Cardiorespiratory fitness and cognition in persons at risk for Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Proceedings from the Albert Charitable Trust Inaugural Workshop on 'Understanding the Acute Effects of Exercise on the Brain'.Brain plasticity (Amsterdam, Netherlands) · 2022Article
- Cardiorespiratory fitness mitigates brain atrophy and cognitive decline in adults at risk for Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Collective effects of age, sex, genotype, and cognitive status on fitness outcomes.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Mitochondrial blood-based biomarker is related to cardiorespiratory fitness and aging in a sex-dependent manner.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
introductionIndividuals with Alzheimer's disease (AD) broadly exhibit lower cardiorespiratory fitness (CRF) compared to cognitively healthy older adults. Other factors, such as increasing age and female sex, are also known to track with lower CRF levels. However, it is unclear how these factors together with AD diagnosis and genetic risk (apolipoprotein e4 ;
methodsOur primary objective was to characterize the collective relationship of age, sex,
resultsAD diagnosis was consistently associated with lower maximal CRF, which declined with increasing age. DISCUSSION: This multi-cohort analysis (n = 304) suggests that
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.