ArticleFrontiers in molecular biosciences2020
Elucidation of Biochemical Pathways Underlying VOCs Production in A549 Cells.
Article in Frontiers in molecular biosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- SPME-based investigation of thapsigargin-induced alterations in the volatilome of human melanoma cells.Analytical and bioanalytical chemistry · 2026Article
- Volatilomic Signatures of Parental and Oxaliplatin-Resistant HCT116 Colon Cancer Cell Lines.International journal of molecular sciences · 2026Article
- Review of cancer cell volatile organic compounds: their metabolism and evolution.Frontiers in molecular biosciences · 2024Review
- Validation of volatile metabolites of pulmonary oxidative injury: a bench to bedside study.ERJ open research · 2023Article
- Hypoxia and lactate influence VOC production in A549 lung cancer cells.Frontiers in molecular biosciences · 2023Article
- The Versatility and Diagnostic Potential of VOC Profiling for Noninfectious Diseases.BME frontiers · 2023Article
- Dissecting the ferroptosis-related prognostic biomarker and immune microenvironment of driver gene-negative lung cancer.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Volatilomic Signatures of AGS and SNU-1 Gastric Cancer Cell Lines.Molecules (Basel, Switzerland) · 2022Article
- Application of Thin-Film Microextraction to Analyze Volatile Metabolites in A549 Cancer Cells.Metabolites · 2021Article
- The Genetic Basis of Tomato Aroma.Genes · 2021Review
- Sample Introduction Method in Gas Chromatography.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021Article
- The Volatilomic Footprints of Human HGC-27 and CLS-145 Gastric Cancer Cell Lines.Frontiers in molecular biosciences · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular volatile organic compounds (VOCs) are unique compounds whose metabolic pathways remain enigmatic. To elucidate their metabolism, we investigated the VOCs of lung cancer A549 and 2 non-cancer lung cells (HLB; HBEpC). Neutral sugars and lactate in the medium were measured by colorimetric assay. VOCs were enriched by monotrap and profiled by GC-MS. To investigate the enzymes that change VOC metabolism in cells, we conducted ALDH activity assays and qPCR. ROS (reactive oxygen species) assays were conducted to assess oxidation stress. The colorimetric assay showed that especially A549 and HLB took up sugars from the medium and rapidly secreted lactate into the medium. The VOC profile (GC-MS) revealed a
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