ArticleJournal of traditional and complementary medicine2020
HIV-1 protease and reverse transcriptase inhibition by tiger milk mushroom (
Article in Journal of traditional and complementary medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 44 citations in OpenAlex.
- Protective effects of tiger milk mushroom extract (xLr®) against UVB irradiation inJournal of traditional and complementary medicine · 2025Article
- Shifting archetype to nature's hidden gems: from sources, purification to uncover the nutritional potential of bioactive peptides.3 Biotech · 2023Review
- Computational studies on searching potential phytochemicals against DNA polymerase activity of the monkeypox virus.Journal of traditional and complementary medicine · 2023Article
- Review
- The structural, dynamic, and thermodynamic basis of darunavir resistance of a heavily mutated HIV-1 protease using molecular dynamics simulation.Frontiers in molecular biosciences · 2022Article
- HIV-1 Protease and Reverse Transcriptase Inhibitory Activities ofPharmaceuticals (Basel, Switzerland) · 2021Article
- Natural Products-Based Drug Design against SARS-CoV-2 Mpro 3CLpro.International journal of molecular sciences · 2021Article
- Narrative Review: Bioactive Potential of Various Mushrooms as the Treasure of Versatile Therapeutic Natural Product.Journal of fungi (Basel, Switzerland) · 2021Review
- Effect of tiger milk mushroom (Lignosus rhinocerus) supplementation on respiratory health, immunity and antioxidant status: an open-label prospective study.Scientific reports · 2021Article
- Extracts of the Tiger Milk Mushroom (Pharmaceuticals (Basel, Switzerland) · 2021Article
- Article
- A critical review on submerged production of mushroom and their bioactive metabolites.3 Biotech · 2020Review
- Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses.Molecules (Basel, Switzerland) · 2020Review
- Anti-HIV-1 protease activity of the crude extracts and isolated compounds from Auricularia polytricha.BMC complementary and alternative medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimEXPERIMENTAL PROCEDURE: The crude hexane (LRH), ethanol (LRE) and water (LRW) extracts of LR were RESULTS AND
conclusionAccording to our screening assays, LRE and LRW significantly inhibited both enzymes (25-55%), while LRH suppressed only the HIV-1 PR activity (88.97%). At 0.5 mg/ml of LRW showed significant inhibition of HIV-1 induced syncytial formation and p24 production in the infected MOLT-4 cells. Investigation of chemical analysis revealed that major groups of identified constituents found in the extracts were fatty acids, peptides and terpenoids.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.