ArticleCardiovascular diagnosis and therapy2020
Obesity-related ventricular remodelling is exacerbated in dilated and hypertrophic cardiomyopathy.
Article in Cardiovascular diagnosis and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- MR Derived Cardiac Metabolism Changes in Patients With Obesity and Diabetes: Knowledge Discovery Via Bayesian Networks and Random Forest Classification.NMR in biomedicine · 2026Article
- Obesity and heart failure: exploring the cardiometabolic axis.Cardiovascular research · 2025Review
- The Impact of Cardio-Renal-Metabolic Profile in Dilated Cardiomyopathy.Current cardiology reports · 2025Review
- Characterization of Non-Ischemic Dilated Cardiomyopathy in a Native Tanzanian Cohort: MOYO Study.Global heart · 2024Article
- The weight of obesity in hypertrophic cardiomyopathy.Clinical medicine (London, England) · 2023Review
- Obesity Cardiomyopathy in Sudden Cardiac Death: A Distinct Entity? A Comparative Study.JACC. Advances · 2023Article
- Exploring the Role of Obesity in Dilated Cardiomyopathy Based on Bio-informatics Analysis.Journal of cardiovascular development and disease · 2022Article
- Unraveling the Genotype-Phenotype Relationship in Hypertrophic Cardiomyopathy: Obesity-Related Cardiac Defects as a Major Disease Modifier.Journal of the American Heart Association · 2020Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundObesity causes significant cardiac remodelling even in health, and yet the contribution of this maladaptation in the setting of an additional cardiomyopathic process is poorly understood. Cardiovascular magnetic resonance is the gold-standard tool for assessing cardiac geometry, especially in an obese population, and hence perfectly suited to investigate this important question.
methodsUsing data from our extensive imaging registry (n=1,554), we documented the relationship between increasing BMI and left ventricular (LV) remodelling in patients with dilated (DCM; n=529) and hypertrophic cardiomyopathy (HCM; n=297), compared to the normal heart (n=728).
resultsRegardless of cardiac status, increasing BMI resulted in similar increases in LV stroke volume (P>0.18). However, there was a difference in the degree of LV cavity dilatation associated with this change in stroke volume; when compared to normal hearts [increase in end-diastolic volume of 0.7 mL per unit of rising BMI (mL/kg/m
conclusionsIn both DCM and HCM, the increase in stroke volume required by obesity appears to be achieved by excessive LV cavity dilatation. The impact of obesity on LV geometry was more pronounced in concomitant cardiovascular disease, and therefore carries potential to become an important therapeutic target in cardiomyopathy.
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