Evidence map›Paper›PMID 32695399›Full record

ArticleBiomarker research2020

Plasma circulating tumor DNA assessment reveals

Qiong Li, Wei Zhang, Jiali Li, Jingkang Xiong, Jia Liu, Ting Chen, Qin Wen, Yunjing Zeng, Li Gao, Lei Gao and 6 more

Open access · goldAbstract read
In one paragraph

Article in Biomarker research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Liquid Biopsy in B and T Cell Lymphomas: From Bench to Bedside.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. [Progression and application of circulating tumor DNA in lymphoma].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024
    Review
  10. Review
  11. Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Qiong Li *Medical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Wei Zhang *Medical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Jiali LiMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Jingkang XiongMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Jia LiuMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Ting ChenMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Qin WenMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Yunjing ZengMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Li GaoMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Lei GaoMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Cheng ZhangMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Peiyan KongMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Xiangui PengMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Yao LiuMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Xi ZhangMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Jun RaoMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.ORCID 0000-0003-3344-2932
Army Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe early detection of tumors upon initial diagnosis or during routine surveillance is important for improving survival outcomes. Here, we investigated the feasibility and clinical significance of circulating tumor DNA (ctDNA) detection for Extranodal NK/T-cell lymphoma, nasal type (ENTKL).

methodsThe plasma ctDNA assessment was based on blood specimens collected from 65 newly diagnosed patients with ENKTL in the hematology medical center of Xinqiao Hospital. Longitudinal samples collected under chemotherapy were also included. The gene mutation spectrum of ENKTL was analyzed via next generation sequencing.

resultsWe found that the most frequently mutated genes were

conclusionOur results unveil the mutation spectrum of ENKTL patients' plasma, which can be used to monitor the disease status of the patients exactly, and

trial registrationThis study is registered with chictr.org (ChiCTR1800014813, registered 7 February, 2018-Retrospectively registered).

Indexed as

Circulating tumor DNAENKTLMinimal residual diseaseMutation allele frequencyPrognosis

Identifiers

PMID32695399
PMCPMC7366898
OpenAlexW3043729073

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.