ArticleClinical kidney journal2020
Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019.
Article in Clinical kidney journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 7 of them syntheses that pooled it.
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Who cites it
70 citing papers in PubMed, 7 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Global geographic and socioeconomic disparities in COVID-associated acute kidney injury: a systematic review and meta-analysis.Journal of global health · 2025Pooled it
- COVID-19 and Acute Kidney Injury: A Systematic Review.Frontiers in medicine · 2022Pooled it
- Incidence and Outcomes of Acute Kidney Injury in COVID-19: A Systematic Review.Blood purification · 2022Pooled it
- Mortality in patients admitted to intensive care with COVID-19: an updated systematic review and meta-analysis of observational studies.Anaesthesia · 2021Pooled it
- Acute kidney injury and renal replacement therapy in COVID-19 patients: A systematic review and meta-analysis.International immunopharmacology · 2021Pooled it
- Risk Factors for Acute Kidney Injury in Adult Patients With COVID-19: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Technical note and clinical instructions for Acute Kidney Injury (AKI) in patients with Covid-19: Brazilian Society of Nephrology and Brazilian Association of Intensive Care Medicine.Jornal brasileiro de nefrologia · 2020Guideline
- COVID-19 Infection, Drugs, and Liver Injury.Journal of clinical medicine · 2025Review
- Assessing acute kidney injury risk after COVID vaccination and infection in a large cohort study.NPJ vaccines · 2024Article
- Perfusion deficits may underlie lung and kidney injury in severe COVID-19 disease: insights from a multicenter international cohort study.Journal of anesthesia, analgesia and critical care · 2024Review
- Cannabis use associated with lower mortality among hospitalized Covid-19 patients using the national inpatient sample: an epidemiological study.Journal of cannabis research · 2024Article
- Impact of dexamethasone in severe COVID-19-induced acute kidney injury: a multicenter cohort study.Annals of intensive care · 2024Article
- The Role of Extracellular Vesicles in SARS-CoV-2-Induced Acute Kidney Injury: An Overview.Life (Basel, Switzerland) · 2024Review
- SCARF Genes in COVID-19 and Kidney Disease: A Path to Comorbidity-Specific Therapies.International journal of molecular sciences · 2023Review
- Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19.Kidney international reports · 2023Article
- Clinical significance of antinuclear antibody positivity in patients with severe coronavirus disease 2019.The Korean journal of internal medicine · 2023Article
- [Characterization of hospitalized patients with acute kidney injury associated with COVID-19 in Spain: Renal replacement therapy and mortality. FRA-COVID SEN Registry Data].Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia · 2023Article
- Article
- Dialysis resource allocation in critical care: the impact of the COVID-19 pandemic and the promise of big data analytics.Frontiers in nephrology · 2023Review
- Have we missed AINything? Acute interstitial nephritis in SARS-CoV-2 infection and vaccination.Clinical kidney journal · 2022Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronavirus disease 2019 (COVID-19)-associated acute kidney injury (AKI) frequency, severity and characterization in critically ill patients has not been reported.
methodsSingle-centre cohort performed from 3 March 2020 to 14 April 2020 in four intensive care units in Bordeaux University Hospital, France. All patients with COVID-19 and pulmonary severity criteria were included. AKI was defined using Kidney Disease: Improving Global Outcomes (KDIGO) criteria. A systematic urinary analysis was performed. The incidence, severity, clinical presentation, biological characterization (transient versus persistent AKI; proteinuria, haematuria and glycosuria) and short-term outcomes were evaluated.
resultsSeventy-one patients were included, with basal serum creatinine (SCr) of 69 ± 21 µmol/L. At admission, AKI was present in 8/71 (11%) patients. Median [interquartile range (IQR)] follow-up was 17 (12-23) days. AKI developed in a total of 57/71 (80%) patients, with 35% Stage 1, 35% Stage 2 and 30% Stage 3 AKI; 10/57 (18%) required renal replacement therapy (RRT). Transient AKI was present in only 4/55 (7%) patients and persistent AKI was observed in 51/55 (93%). Patients with persistent AKI developed a median (IQR) urine protein/creatinine of 82 (54-140) (mg/mmol) with an albuminuria/proteinuria ratio of 0.23 ± 20, indicating predominant tubulointerstitial injury. Only two (4%) patients had glycosuria. At Day 7 after onset of AKI, six (11%) patients remained dependent on RRT, nine (16%) had SCr >200 µmol/L and four (7%) had died. Day 7 and Day 14 renal recovery occurred in 28% and 52%, respectively.
conclusionSevere COVID-19-associated AKI is frequent, persistent, severe and characterized by an almost exclusive tubulointerstitial injury without glycosuria.
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