Evidence map›Paper›PMID 32695298›Full record

ArticleIranian journal of basic medical sciences2020

The effects of synthetic orally administrated insulin nanoparticles in comparison to injectable insulin on the renal function markers of type 1- diabetic rats.

Nejat Kheiripour, Behnam Alipoor, Akram Ranjbar, Yasin Pourfarjam, Farzaneh Kazemi Najafabadi, Narges Dehkhodaei, Masoumeh Farhadiannezhad, Hassan Ghasemi

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Article in Iranian journal of basic medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Nejat KheiripourResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Behnam AlipoorDepartment of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran.
Akram RanjbarToxicology and Pharmacology Department, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Yasin PourfarjamDepartment of Chemistry, University of Cincinnati, Cincinnati, OH, United States of America.
Farzaneh Kazemi NajafabadiToxicology and Pharmacology Department, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Narges DehkhodaeiToxicology and Pharmacology Department, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Masoumeh FarhadiannezhadStudent Research Committee, Abadan School of Medical Sciences, Abadan, Iran.
Hassan GhasemiDepartment of Clinical Biochemistry, Abadan Faculty of Medical Sciences, Abadan, Iran.
Hamedan University of Medical Sciences · IRKashan University of Medical Sciences · IRUniversity of Cincinnati · USYasuj University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesInjectable insulin is the most widely used therapy in patients with type 1 diabetes which has several disadvantages. The present study was aimed to evaluate the efficacy of injectable insulin on diabetes mellitus-related complications in comparison to orally encapsulated insulin nanoparticles. MATERIALS AND

methodsThis study involved 42 Wistar rats separated into 5 groups, including control (C), diabetic control (D), diabetic receiving regular insulin (INS), diabetic receiving encapsulated insulin nanoparticle (INP), and diabetic receiving chitosan for two months. Biochemical parameters in serum and urine were measured using spectrophotometric or ELISA methods. mRNA levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were evaluated using quantitative PCR.

resultsThere were no significant differences between the two forms of insulin in controlling the glycemic condition (

conclusionOur results suggested that oral INP is more effective than injectable insulin in modulation of urine and serum diabetic-related parameters.

Indexed as

ChitosanDiabetes mellitusInsulin nanoparticleKidney injury molecule 1Neutrophil gelatinase-associated lipocalin protein

Identifiers

PMID32695298
PMCPMC7351444
OpenAlexW3016826878

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.