RP-HPLC Method Development and Validation of Synthesized Codrug in Combination with Indomethacin, Paracetamol, and Famotidine.

Mohyeddin Assali, Murad Abualhasan, Nihal Zohud, Noura Ghazal

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Article in International journal of analytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Method Development for Simultaneously Determining Indomethacin and Nicotinamide in New Combination in Oral Dosage Formulations and Co-Amorphous Systems Using Three UV Spectrophotometric Techniques.International journal of analytical chemistry · 2024
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4 authors.

Mohyeddin AssaliDepartment of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, State of Palestine.ORCID https://orcid.org/0000-0002-2286-9343

Murad AbualhasanDepartment of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, State of Palestine.ORCID https://orcid.org/0000-0002-2083-856X

Nihal ZohudDepartment of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, State of Palestine.ORCID https://orcid.org/0000-0002-6837-1209

Noura GhazalDepartment of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, State of Palestine.ORCID https://orcid.org/0000-0002-4493-5428

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndomethacin is considered a potent nonsteroidal anti-inflammatory drug that could be combined with Paracetamol to have superior and synergist activity to manage pain and inflammation. To reduce the gastric side effect, they could be combined with Famotidine.

resultsThe developed method showed good separation of the four tested drugs with a linear range of 0.01-0.1 mg/mL (

conclusionThe codrug of Indomethacin and Paracetamol was successfully synthesized for the first time. Moreover, the developed analytical method, to our knowledge, is the first of its kind to simultaneously quantify four solutions containing the following active ingredients of codrug, Indomethacin, Paracetamol, and Famotidine mixture with added pharmaceutical inactive ingredients in one HPLC run.

Identifiers

PMID32695171

DOI10.1155/2020/1894907

PMCPMC7350129

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