Evidence map›Paper›PMID 32695072›Full record

ArticleFrontiers in microbiology2020

Wild-Type MIC Distribution for Re-evaluating the Critical Concentration of Anti-TB Drugs and Pharmacodynamics Among Tuberculosis Patients From South India.

Azger Dusthackeer, Shainaba A Saadhali, Manonanthini Thangam, Sameer Hassan, Mahizhaveni Balasubramanian, Angayarkani Balasubramanian, Geetha Ramachandran, A K Hemanth Kumar, Kannan Thiruvenkadam, Govindarajan Shanmugam and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Azger DusthackeerDepartment of Bacteriology, National Institute for Research in Tuberculosis, Chennai, India.
Shainaba A SaadhaliDepartment of Bacteriology, National Institute for Research in Tuberculosis, Chennai, India.
Manonanthini ThangamAU-KBC Research Centre, Anna University, Chennai, India.
Sameer HassanDivision of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.
Mahizhaveni BalasubramanianDepartment of Bacteriology, National Institute for Research in Tuberculosis, Chennai, India.
Angayarkani BalasubramanianDepartment of Bacteriology, National Institute for Research in Tuberculosis, Chennai, India.
Geetha RamachandranDepartment of Biochemistry, National Institute for Research in Tuberculosis, Chennai, India.
A K Hemanth KumarDepartment of Biochemistry, National Institute for Research in Tuberculosis, Chennai, India.
Kannan ThiruvenkadamDepartment of Epidemiology, National Institute for Research in Tuberculosis, Chennai, India.
Govindarajan ShanmugamDepartment of Bacteriology, National Institute for Research in Tuberculosis, Chennai, India.
Christy Rosaline NirmalDepartment of Bacteriology, National Institute for Research in Tuberculosis, Chennai, India.
Sam Ebenezer RajadasDepartment of Bacteriology, National Institute for Research in Tuberculosis, Chennai, India.
Sucharitha Kannappan MohanvelCAS in Botany, University of Madras, Chennai, India.
Rajesh MondalDepartment of Bacteriology, National Institute for Research in Tuberculosis, Chennai, India.
National Institute of Research in Tuberculosis · INAnna University, Chennai · INKarolinska Institutet · SEUniversity of Madras · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The World Health Organization (WHO) has developed specific guidelines for critical concentrations (CCs) of antibiotics used for tuberculosis (TB) treatment, which is universally followed for drug susceptibility testing (DST) of clinical specimens. However, the CC of drugs can differ significantly among the mycobacterial species based on the population, geographic location, and the prevalence of the infecting strain in a particular area. The association between CC and the minimal inhibitory concentration (MIC) of anti-TB drugs is poorly understood. In this study, we assessed the MICs of anti-TB drugs, including isoniazid (INH), rifampicin (RMP), moxifloxacin (MXF), ethambutol (ETH), and

Indexed as

critical concentrationdrug resistanceminimum inhibitory concentration (MIC)pharmacodynamics (PD)tuberculosis

Identifiers

PMID32695072
PMCPMC7338667
OpenAlexW3038114379

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.