Evidence map›Paper›PMID 32694981›Full record

ArticleFrontiers in molecular neuroscience2020

Dabigatran Suppresses PAR-1/SphK/S1P Activation of Astrocytes in Experimental Autoimmune Encephalomyelitis Model.

Rong Chen, Xing Cao, Wenxiu Luo, Haodi Yang, Xinya Luo, Juming Yu, Jiaming Luo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Interferon-Disease markers · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rong ChenDepartment of Microbiology and Immunology, North Sichuan Medical College, Nanchong, China.
Xing CaoDepartment of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Wenxiu LuoDepartment of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Haodi YangDepartment of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Xinya LuoDepartment of Anesthesia, North Sichuan Medical College, Nanchong, China.
Juming YuDepartment of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Jiaming LuoDepartment of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Affiliated Hospital of North Sichuan Medical College · CNNorth Sichuan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is an inflammatory autoimmune disease affecting the central nervous system (CNS) that currently does not have any effective treatment. Experimental autoimmune encephalomyelitis (EAE) is often employed as a model to mimic the clinical manifestations of MS, mainly CNS demyelination. Coagulation is known to participate in crosstalk with inflammation and autoimmunity. We herein explored the correlation between the coagulation cascade and CNS immune diseases

Indexed as

coagulationdabigatranexperimental autoimmune encephalomyelitismultiple sclerosisprotease-activated receptorssphingosine-1-phosphate

Identifiers

PMID32694981
PMCPMC7338760
OpenAlexW3037760671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.