Evidence map›Paper›PMID 32694927›Full record

ArticleMediators of inflammation2020

Biological Characterization of Commercial Recombinantly Expressed Immunomodulating Proteins Contaminated with Bacterial Products in the Year 2020: The SAA3 Case.

Sara Abouelasrar Salama, Mirre De Bondt, Nele Berghmans, Mieke Gouwy, Vivian Louise Soares de Oliveira, Sergio C Oliveira, Flavio A Amaral, Paul Proost, Jo Van Damme, Sofie Struyf and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. SAA4: An Underdog Within the Serum Amyloid a Superfamily?International journal of molecular sciences · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Sara Abouelasrar SalamaKU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory of Molecular Immunology, Herestraat 49, Box 1042, 3000 Leuven, Belgium.
Mirre De BondtKU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory of Molecular Immunology, Herestraat 49, Box 1042, 3000 Leuven, Belgium.
Nele BerghmansKU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory of Molecular Immunology, Herestraat 49, Box 1042, 3000 Leuven, Belgium.
Mieke GouwyKU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory of Molecular Immunology, Herestraat 49, Box 1042, 3000 Leuven, Belgium.
Vivian Louise Soares de OliveiraImunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, Pampulha, Belo Horizonte, 31270-901 Minas Gerais, Brazil.
Sergio C OliveiraDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, Pampulha, Belo Horizonte, 31270-901 Minas Gerais, Brazil.
Flavio A AmaralImunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, Pampulha, Belo Horizonte, 31270-901 Minas Gerais, Brazil.
Paul ProostKU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory of Molecular Immunology, Herestraat 49, Box 1042, 3000 Leuven, Belgium.
Jo Van DammeKU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory of Molecular Immunology, Herestraat 49, Box 1042, 3000 Leuven, Belgium.
Sofie StruyfKU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory of Molecular Immunology, Herestraat 49, Box 1042, 3000 Leuven, Belgium.
Mieke De BuckKU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory of Molecular Immunology, Herestraat 49, Box 1042, 3000 Leuven, Belgium.ORCID https://orcid.org/0000-0002-9420-0630
Rega Institute for Medical Research · BEUniversidade Federal de Minas Gerais · BR

Funding

Brucella survival strategy requires endoplasmic reticulum restructuring and interferes with innate immunityR01AI116453 · NIAID · FOUNDATION FOR RESEARCH DEVELOPMENT · PI BARBER, GLEN N, OLIVEIRA, SERGIO C · 2016 to 2025
$1.4M
NIAID NIH HHS R01 AI116453
6 · The paper itself

Abstract

The serum amyloid A (SAA) gene family is highly conserved and encodes acute phase proteins that are upregulated in response to inflammatory triggers. Over the years, a considerable amount of literature has been published attributing a wide range of biological effects to SAAs such as leukocyte recruitment, cytokine and chemokine expression and induction of matrix metalloproteinases. Furthermore, SAAs have also been linked to protumorigenic, proatherogenic and anti-inflammatory effects. Here, we investigated the biological effects conveyed by murine SAA3 (mu rSAA3) recombinantly expressed in

Indexed as

AnimalsCarcinoma, Lewis LungChemokine CCL2Chemokine CCL3Chemokine CXCL1Chemokine CXCL2Chemokine CXCL6Chromatography, High Pressure LiquidEnzyme-Linked Immunosorbent AssayEscherichia coliFlow CytometryHumansInterleukin-8LipopolysaccharidesLipoproteinsMiceChemokine CCL2Chemokine CCL3Chemokine CXCL1Chemokine CXCL2Chemokine CXCL6Interleukin-8LipopolysaccharidesLipoproteinsSaa3 protein, mouseSerum Amyloid A Protein

Identifiers

PMID32694927
PMCPMC7362292
OpenAlexW3040572687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.