Evidence map›Paper›PMID 32694925›Full record

ArticleMediators of inflammation2020

Associations of Serological Biomarkers of sICAM-1, IL-1

Xuran Li, Ying Zhou, Ruyi Zou, Haoran Chen, Xiaoqin Liu, Xiaohua Qiu, Yonglong Xiao, Hourong Cai, Jinghong Dai

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Acute Exacerbations of Interstitial Lung Diseases: Focus on Biomarkers.International journal of molecular sciences · 2023
    Review
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xuran LiDepartment of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical School, Nanjing, Jiangsu, China.ORCID https://orcid.org/0000-0002-5036-1854
Ying ZhouDepartment of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical School, Nanjing, Jiangsu, China.
Ruyi ZouDepartment of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical School, Nanjing, Jiangsu, China.
Haoran ChenDepartment of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical School, Nanjing, Jiangsu, China.
Xiaoqin LiuDepartment of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical School, Nanjing, Jiangsu, China.
Xiaohua QiuDepartment of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical School, Nanjing, Jiangsu, China.ORCID https://orcid.org/0000-0001-6348-1348
Yonglong XiaoDepartment of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical School, Nanjing, Jiangsu, China.ORCID https://orcid.org/0000-0003-1194-1394
Hourong CaiDepartment of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical School, Nanjing, Jiangsu, China.ORCID https://orcid.org/0000-0001-7618-6436
Jinghong DaiDepartment of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical School, Nanjing, Jiangsu, China.ORCID https://orcid.org/0000-0003-3165-0623
Nanjing Drum Tower Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate prognostic values of serum biomarkers of soluble intercellular adhesion molecule 1 (sICAM-1), macrophage migration inhibitor factor (MIF), interleukin 1

methodsFrom August 2017 to November 2019, 122 consecutive IPF patients treated in our center were classified as stable IPF and AE-IPF based on the newly published international guidelines. Serum levels of four biomarkers at admission were measured by the enzyme-linked immunosorbent assay (ELISA). The primary endpoint was 3-month mortality. The log-rank test and logistic regression analysis were used to evaluate the effects of these biomarkers for survival in patients with AE-IPF. Cox proportional hazards analysis was performed to evaluate the prognostic values of serological biomarkers and clinical data.

resultsEighty-one patients were diagnosed with stable IPF, and 41 AE-IPF patients were enrolled in the study. Serum levels of sICAM-1 (

conclusionsWe showed the higher serum levels of IL-1

Indexed as

AdultAgedAged, 80 and overBiomarkersEnzyme-Linked Immunosorbent AssayFemaleHumansIdiopathic Pulmonary FibrosisIntercellular Adhesion Molecule-1Interleukin-1betaIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMaleMiddle AgedBiomarkersIntercellular Adhesion Molecule-1Interleukin-1betaIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMIF protein, human

Identifiers

PMID32694925
PMCPMC7362287
OpenAlexW3039811599

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.