Evidence map›Paper›PMID 32694898›Full record

ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2020

Low-depth whole genome sequencing reveals copy number variations associated with higher pathologic grading and more aggressive subtypes of lung non-mucinous adenocarcinoma.

Zheng Wang, Lin Zhang, Lei He, Di Cui, Chenglong Liu, Liangyu Yin, Min Zhang, Lei Jiang, Yuyan Gong, Wang Wu and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Novel technologies in cfDNA analysis and potential utility in clinic.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2021
    Article
  2. Cell-free DNA in the surveillance of heart transplant rejection.Indian journal of thoracic and cardiovascular surgery · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Zheng WangDepartment of Pathology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Lin ZhangDepartment of Pathology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Lei HeDepartment of Pathology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Di CuiDepartment of Pathology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Chenglong LiuDepartment of Pathology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Liangyu YinDepartment of Pathology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Min ZhangDepartment of Radiology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Lei JiangDepartment of Radiology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Yuyan GongBerry Genomics Corporation, Beijing 102206, China.
Wang WuBerry Genomics Corporation, Beijing 102206, China.
Bi LiuBerry Genomics Corporation, Beijing 102206, China.
Xiaoyu LiBerry Genomics Corporation, Beijing 102206, China.
David S CramBerry Genomics Corporation, Beijing 102206, China.
Dongge LiuDepartment of Pathology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Beijing Hospital · CNBerry Oncology (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHistology grade, subtypes and TNM stage of lung adenocarcinomas are useful predictors of prognosis and survival. The aim of the study was to investigate the relationship between chromosomal instability, morphological subtypes and the grading system used in lung non-mucinous adenocarcinoma (LNMA).

methodsWe developed a whole genome copy number variation (WGCNV) scoring system and applied next generation sequencing to evaluate CNVs present in 91 LNMA tumor samples.

resultsHigher histological grades, aggressive subtypes and more advanced TNM staging were associated with an increased WGCNV score, particularly in CNV regions enriched for tumor suppressor genes and oncogenes. In addition, we demonstrate that 24-chromosome CNV profiling can be performed reliably from specific cell types (<100 cells) isolated by sample laser capture microdissection.

conclusionsOur findings suggest that the WGCNV scoring system we developed may have potential value as an adjunct test for predicting the prognosis of patients diagnosed with LNMA.

Indexed as

copy number variations (CNVs)histological gradingLung adenocarcinomalung non-mucinous adenocarcinoma (LNMA)TNM stagingwhole genome copy number variation (WGCNV) score

Identifiers

PMID32694898
PMCPMC7369181
OpenAlexW3041676066

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.