ArticleScientific reports2020
Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Alterations in blood pressure dependent activation of leg muscles during standing following bed rest mimic those observed with ageing.Frontiers in physiology · 2025Article
- A review of the physiological effects of microgravity and innovative formulation for space travelers.Journal of pharmacokinetics and pharmacodynamics · 2024Review
- Retinal blood vessel diameter changes with 60-day head-down bedrest are unaffected by antioxidant nutritional cocktail.NPJ microgravity · 2024Article
- Navigating Complexity in Postural Orthostatic Tachycardia Syndrome.Biomedicines · 2024Review
- The Effect of Skeletal Muscle-Pump on Blood Pressure and Postural Control in Parkinson's Disease.Cardiovascular engineering and technology · 2023Article
- Exaggerated postural sway improves orthostatic cardiovascular and cerebrovascular control.Frontiers in cardiovascular medicine · 2023Article
- Elevated biomarkers of neural injury in older adults following head-down bed rest: links to cardio-postural deconditioning with spaceflight and aging.Frontiers in human neuroscience · 2023Article
- Article
- Mechanical deconditioning of the heart due to long-term bed rest as observed on seismocardiogram morphology.NPJ microgravity · 2022Article
- Effect of Parkinson's Disease on Cardio-postural Coupling During Orthostatic Challenge.Frontiers in physiology · 2022Article
- Canadian aging and inactivity study: Spaceflight-inspired exercises during head-down tilt bedrest blunted reductions in muscle-pump but not cardiac baroreflex in older persons.Frontiers in physiology · 2022Article
- Psychophysiological Indicators of Postural Control. Contribution of the Russian Scientific School. Part I.Human physiology · 2022Article
- Article
- Correlation between timed up and go test and skeletal muscle tensiomyography in female nursing home residents.Journal of musculoskeletal & neuronal interactions · 2021Article
- Falls Risk, Circadian Rhythms and Melatonin: Current Perspectives.Clinical interventions in aging · 2020Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand fundamental mechanisms associated with post-flight orthostatic intolerance we investigated the interaction between the cardiovascular and postural functions before and after 60 days of head down bedrest (HDBR). Twenty healthy young males (35.0 ± 1.7 years) were subjected to 60-day HDBR at 6˚ to simulate spaceflight-induced fluid shifts. A supine-to-stand (STS) test was conducted to evaluate cardio-postural control before and after (R) HDBR while an assessment of cardiovascular function was performed during HDBR. Beat-to-beat heart period, systolic blood pressure, and electromyography impulses were derived for wavelet transform coherence and causality analyses of the cardio-postural control and used to assess changes in the muscle-pump baroreflex. During quiet stand of the STS test, compared to baseline, heart rate was 50% higher on the day of exit from bedrest (R0) and 20% higher eight days later (R8). There was a 50% increase in deoxygenated hemoglobin on R0 and R8. Leg muscle activity reduced, and postural sway increased after HDBR. Causality of the muscle-pump baroreflex was reduced on R0 (0.73 ± 0.2) compared to baseline (0.87 ± 0.2) with complete recovery by R8. The muscle-pump baroreflex also had decreased gain and fraction time active following HDBR. Overall, our data show a significantly impaired muscle-pump baroreflex following bedrest.
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