ArticleNature metabolism2020
PTH hypersecretion triggered by a GABA
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Article in Nature metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Acidic extracellular pH-induced PTH secretion in male mouse parathyroids is OGR1-dependent.Endocrinology · 2026Article
- Fibrosis suppressive effect and mechanism of CaSR positive allosteric modulators/p-dioxanone copolymers.Drug delivery and translational research · 2026Article
- A novel homozygous inactivating mutation of the calcium-sensing receptor causing familial hypocalciuric hypercalcemia complicated with primary hyperparathyroidism due to parathyroid adenoma: A case report.The Journal of international medical research · 2026Article
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- Causal Relationships Between Epilepsy, Anti-Epileptic Drugs, and Serum Vitamin D and Vitamin D Binding Protein: A Bidirectional and Drug Target Mendelian Randomization Study.CNS neuroscience & therapeutics · 2024Article
- Large library docking identifies positive allosteric modulators of the calcium-sensing receptor.Science (New York, N.Y.) · 2024Article
- Small vs. Large Library Docking for Positive Allosteric Modulators of the Calcium Sensing Receptor.bioRxiv : the preprint server for biology · 2024Article
- Gestational Ectopic Hyperparathyroidism: A Case Report of Perioperative and Perinatal Outcomes.Cureus · 2024Article
- Digital spatial profiling of human parathyroid tumors reveals cellular and molecular alterations linked to vitamin D deficiency.PNAS nexus · 2023Article
- tRNA-Uridine Aminocarboxypropyltransferase DTW Domain Containing 2 Suppresses Colon Adenocarcinoma Progression.International journal of genomics · 2023Article
- The Identification of Immune-Related Biomarkers for Osteoarthritis Immunotherapy Based on Single-Cell RNA Sequencing Analysis.Genetics research · 2023Article
- Transmembrane protein 88 suppresses hepatocellular carcinoma progression and serves as a novel prognostic factor.Frontiers in oncology · 2023Article
- Germinal Center-Related G Protein-Coupled Receptors in Antibody-Mediated Autoimmune Skin Diseases: from Basic Research to Clinical Trials.Clinical reviews in allergy & immunology · 2022Review
- Epidemiology, Pathophysiology, and Genetics of Primary Hyperparathyroidism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Review
- Cinacalcet inhibition of neuronal action potentials preferentially targets the fast inactivated state of voltage-gated sodium channels.Frontiers in physiology · 2022Article
- Article
- Article
- Ex Vivo Intact Tissue Analysis Reveals Alternative Calcium-sensing Behaviors in Parathyroid Adenomas.The Journal of clinical endocrinology and metabolism · 2021Article
- Article
- Molecular mechanisms of metabotropic GABAScience advances · 2021Review
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 2 countries.
Wenhan ChangEndocrine Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA, USA. wenhan.chang@ucsf.edu.ORCID http://orcid.org/0000-0001-6583-7176
Chia-Ling TuEndocrine Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA, USA.
Frederic G Jean-AlphonseLaboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Amanda HerbergerEndocrine Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA, USA.
Zhiqiang ChengEndocrine Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA, USA.
Jenna HwongEndocrine Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA, USA.
Hanson HoEndocrine Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA, USA.
Alfred LiEndocrine Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA, USA.
Dawei WangLaboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Hongda LiuLaboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Alex D WhiteLaboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Insoo SuhDepartment of Surgery, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6911-2324
Wen ShenDepartment of Surgery, University of California, San Francisco, CA, USA.
Quan-Yang DuhDepartment of Surgery, University of California, San Francisco, CA, USA.
Elham KhanafsharDepartment of Pathology, University of California, San Francisco, CA, USA.
Dolores M ShobackEndocrine Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA, USA.
Kunhong XiaoLaboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jean-Pierre VilardagaLaboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. jpv@pitt.edu.ORCID http://orcid.org/0000-0002-1217-1435
San Francisco VA Medical Center · USUniversity of Pittsburgh · USUniversity of California, San Francisco · USSun Yat-sen University · CN
Funding
Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 2019 to 2026
$7.1MStructure and function of PTH class B GPCRR01DK116780 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ivet Bahar, Jean-Pierre Vilardaga · 2018 to 2026
$4.2MPREDOCTORAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM008424 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAGANO, PATRICK J · 1994 to 2019
$3.4MUCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2014 to 2018
$3.0MFunctional Polarity of PTH Receptor Signaling: Cellular and Molecular MechanismsR01DK111427 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRIEDMAN, PETER A, VILARDAGA, JEAN-PIERRE · 2017 to 2020
$2.4MRegulation of Parathyroid Functions By G-Protein Coupled ReceptorsR01DK122259 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI CHANG, WENHAN, VILARDAGA, JEAN-PIERRE · 2019 to 2023
$2.2MRegulation of PTH secretion by TRPC1R01DK121656 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CHANG, WENHAN, TSIOKAS, LEONIDAS · 2019 to 2022
$2.1MStructural and Functional Mechanisms of PTH-Receptor SignalingR01DK102495 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CALERO, GUILLERMO ALBERTO, GARDELLA, THOMAS J · 2014 to 2017
$2.0MCombined PTH and Calcimimetic Therapy and Its Mechanisms for OsteoanabolismR01AR067291 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI CHANG, WENHAN · 2015 to 2019
$1.7MSustained cAMP Signals Triggered by Internalized PTH Receptor: New Consequences fR01DK087688 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VILARDAGA, JEAN-PIERRE · 2010 to 2014
$1.6MCalcium-sensing Receptor and Keratinocyte DifferentiationR01AR056256 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI TU, CHIA-LING · 2010 to 2014
$1.6MThe Endocrine and Skeletal Actions of the PTG-derived Cyp27b1F32DK107177 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI HERBERGER, AMANDA · 2016 to 2018
$178kBLRD VA I01 BX001960BLRD VA I01 BX003453BLRD VA IK6 BX004835NIAMS NIH HHS P30 AR066262NIAMS NIH HHS P30 AR075055NIAMS NIH HHS R01 AR056256NIAMS NIH HHS R01 AR067291NIDDK NIH HHS F32 DK107177NIDDK NIH HHS R01 DK087688NIDDK NIH HHS R01 DK102495NIDDK NIH HHS R01 DK111427NIDDK NIH HHS R01 DK116780NIDDK NIH HHS R01 DK121656NIDDK NIH HHS R01 DK122259NIGMS NIH HHS T32 GM008424
Abstract
Molecular mechanisms mediating tonic secretion of parathyroid hormone (PTH) in response to hypocalcaemia and hyperparathyroidism (HPT) are unclear. Here we demonstrate increased heterocomplex formation between the calcium-sensing receptor (CaSR) and metabotropic γ-aminobutyric acid (GABA) B
Indexed as
AnimalsCalciumgamma-Aminobutyric AcidHumansHyperparathyroidism, SecondaryHypocalcemiaMiceParathyroid HormoneReceptors, Calcium-SensingReceptors, GABA-BCalciumgamma-Aminobutyric AcidParathyroid HormoneReceptors, Calcium-SensingReceptors, GABA-B
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.