ArticleNature metabolism2020
Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism.
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Article in Nature metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
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Who cites it
36 citing papers in PubMed, 62 citations in OpenAlex.
- Review
- FTO-Catalysed Demethylation of LUR1 mRNA Suppresses Macrophage Lipid Accumulation and Aortic Atherosclerosis.Journal of cellular and molecular medicine · 2026Article
- Aspartate availability drives differential engagement of the malate-aspartate shuttle.Molecular cell · 2026Article
- Targeting C12ORF49-Mediated Ferroptosis in Hepatocellular Carcinoma.JGH open : an open access journal of gastroenterology and hepatology · 2026Review
- A Co-essentiality Network of Cancer Driver Genes Better Prioritizes Anticancer Drugs.Genomics, proteomics & bioinformatics · 2025Article
- Article
- Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia.Nature metabolism · 2025Article
- ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver.Communications biology · 2025Article
- SPRINGing off the lock: the role of SPRING in S1P activity and SREBP-regulated lipid metabolism.Current opinion in lipidology · 2025Review
- Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma.Cancer communications (London, England) · 2025Article
- Targeting the WSB2-NOXA axis in cancer cells for enhanced sensitivity to BCL-2 family protein inhibitors.eLife · 2025Article
- Structural basis for substrate selectivity by site-one protease revealed by studies with a small-molecule inhibitor.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- C12ORF49 inhibits ferroptosis in hepatocellular carcinoma cells via reprogramming SREBP1/SCD1-mediated lipid metabolism.Cell death discovery · 2025Article
- PPTC7 acts as an essential co-factor of the SCFCell death & disease · 2025Article
- SREBP2 as a central player in cancer progression: potential for targeted therapeutics.Frontiers in pharmacology · 2025Review
- SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain.Nature communications · 2024Article
- On knowing a gene: A distributional hypothesis of gene function.Cell systems · 2024Review
- SPRING is a Dedicated Licensing Factor for SREBP-Specific Activation by S1P.Molecular and cellular biology · 2024Article
- Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans.Nature communications · 2023Article
- Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma.Nature communications · 2023Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 1 country.
Erol C BayraktarLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Konnor LaLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Kara KarpmanCenter for Applied Mathematics, Cornell University, Ithaca, NY, USA.
Gokhan UnluLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-2704-2724
Ceren OzerdemLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0001-6772-0422
Dylan J RitterDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-8704-908X
Hanan AlwaseemProteomics Resource Center, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-4946-1436
Henrik MolinaProteomics Resource Center, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0001-8950-4990
Hans-Heinrich HoffmannLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
Alec MillnerDepartment of Chemistry, University at Buffalo, The State University of New York (SUNY), Buffalo, NY, USA.
G Ekin Atilla-GokcumenDepartment of Chemistry, University at Buffalo, The State University of New York (SUNY), Buffalo, NY, USA.
Eric R GamazonDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-4204-8734
Amy R RushingDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Ela W KnapikDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-2977-3619
Sumanta BasuDepartment of Statistics and Data Science, Cornell University, Ithaca, NY, USA.
Kıvanç BirsoyLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA. kbirsoy@rockefeller.edu.ORCID http://orcid.org/0000-0002-7579-9895
Rockefeller University · USVanderbilt University · USCornell University · USUniversity at Buffalo, State University of New York · USVanderbilt University Medical Center · US
Funding
Discovering Biology for Neuropsychiatric Diseases Through Omics Studies on ComorbiditiesR01MH113362 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COX, NANCY J, KNAPIK, ELA W · 2017 to 2021
$3.9MControl of COPII vesicle trafficking by intracellular protein glycosylationR01GM117473 · NIGMS · DUKE UNIVERSITY · PI BOYCE, MICHAEL S · 2017 to 2025
$2.6MIdentification of metabolic regulators of glycerolipid synthesis and storageR01DK123323 · NIDDK · ROCKEFELLER UNIVERSITY · PI BIRSOY, KIVANC · 2019 to 2023
$2.5MFunctional Genomics: A Phenome-wide SurveyR35HG010718 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GAMAZON, ERIC R · 2019 to 2023
$2.2MLearning Dynamics of Biological Processes from Time Course Omics DatasetsR01GM135926 · NIGMS · CORNELL UNIVERSITY · PI BASU, SUMANTA · 2019 to 2022
$1.4MThe role of RGP1 in extracellular matrix secretion and chondrocyte cell shape developmentF31DE030007 · NIDCR · VANDERBILT UNIVERSITY · PI RITTER, DYLAN · 2020 to 2022
$84kNHGRI NIH HHS R35 HG010718NIDCR NIH HHS F31 DE030007NIDDK NIH HHS R01 DK123323NIGMS NIH HHS R01 GM117473NIGMS NIH HHS R01 GM135926NIMH NIH HHS R01 MH113362
Abstract
Coessentiality mapping has been useful to systematically cluster genes into biological pathways and identify gene functions
Indexed as
AnimalsCell LineCell ProliferationCholesterolGene Expression RegulationGolgi ApparatusHumansHyperlipidemiasLipid MetabolismMembrane ProteinsProprotein ConvertasesSerine EndopeptidasesSterol Regulatory Element Binding ProteinsZebrafishCholesterolmembrane-bound transcription factor peptidase, site 1Membrane ProteinsProprotein ConvertasesSerine EndopeptidasesSPRING1 protein, humanSterol Regulatory Element Binding Proteins
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