Evidence map›Paper›PMID 32694602›Full record

ArticleScientific reports2020

Simultaneous FDG-PET/MRI detects hippocampal subfield metabolic differences in AD/MCI.

Mackenzie L Carlson, Phillip S DiGiacomo, Audrey P Fan, Maged Goubran, Mohammad Mehdi Khalighi, Steven Z Chao, Minal Vasanawala, Max Wintermark, Elizabeth Mormino, Greg Zaharchuk and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mackenzie L CarlsonDepartment of Bioengineering, Stanford University, Stanford, USA.
Phillip S DiGiacomoDepartment of Bioengineering, Stanford University, Stanford, USA.
Audrey P FanDepartment of Radiology, Stanford University, Stanford, USA.
Maged GoubranDepartment of Radiology, Stanford University, Stanford, USA.
Mohammad Mehdi KhalighiDepartment of Radiology, Stanford University, Stanford, USA.
Steven Z ChaoDepartment of Neurology, Stanford University, Stanford, USA.
Minal VasanawalaDepartment of Radiology, Stanford University, Stanford, USA.
Max WintermarkDepartment of Radiology, Stanford University, Stanford, USA.
Elizabeth MorminoDepartment of Neurology, Stanford University, Stanford, USA.
Greg ZaharchukDepartment of Radiology, Stanford University, Stanford, USA.
Michelle L JamesDepartment of Radiology, Stanford University, Stanford, USA.
Michael M ZeinehDepartment of Radiology, Stanford University, Stanford, USA. mzeineh@stanford.edu.

Funding

Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI LU TIAN · 2020 to 2026
$29.0M
Iron as an Imaging Biomarker for Inflammation in ADR01AG061120 · NIA · STANFORD UNIVERSITY · PI ZEINEH, MICHAEL M · 2019 to 2023
$3.5M
Predoctoral Training in Biomedical Imaging at Stanford UniversityT32EB009653 · NIBIB · STANFORD UNIVERSITY · PI BUTTS-PAULY, KIM · 2010 to 2019
$2.1M
Quantitative PET/MRI of brain oxygenation in cerebrovascular diseaseK99NS102884 · NINDS · STANFORD UNIVERSITY · PI FAN, AUDREY PEIWEN · 2018 to 2019
$170k
NIA NIH HHS P30 AG066515NIA NIH HHS R01 AG061120NIA NIH HHS R01AG061120NIBIB NIH HHS T32 EB009653NIH HHS 5K99NS102884-02NINDS NIH HHS K99 NS102884
6 · The paper itself

Abstract

The medial temporal lobe is one of the most well-studied brain regions affected by Alzheimer's disease (AD). Although the spread of neurofibrillary pathology in the hippocampus throughout the progression of AD has been thoroughly characterized and staged using histology and other imaging techniques, it has not been precisely quantified in vivo at the subfield level using simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI). Here, we investigate alterations in metabolism and volume using [

Indexed as

Fluorodeoxyglucose F18Magnetic Resonance ImagingPositron-Emission TomographyAgedAlzheimer DiseaseBrainCase-Control StudiesFemaleHippocampusHumansMaleMiddle AgedFluorodeoxyglucose F18

Identifiers

PMID32694602
PMCPMC7374580

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.