ArticleScientific reports2020
Impact of solid surface hydrophobicity and micrococcal nuclease production on Staphylococcus aureus Newman biofilms.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
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- Dialkyl Carbamoyl Chloride-Coated Dressing Prevents Macrophage and Fibroblast Stimulation via Control of Bacterial Growth: An In Vitro Assay.Microorganisms · 2022Article
- Analysis of Microorganism Colonization, Biofilm Production, and Antibacterial Susceptibility in Recurrent Tonsillitis and Peritonsillar Abscess Patients.International journal of molecular sciences · 2022Article
- Seaweed Extracts as an Effective Gateway in the Search for Novel Antibiofilm Agents againstPlants (Basel, Switzerland) · 2022Article
- Effect of Cobalt-Chromium-Molybdenum Implant Surface Modifications on Biofilm Development ofFrontiers in cellular and infection microbiology · 2022Article
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- Evaluation of the most promising techniques overcoming the algal problems takes place during the purification of drinking water.Environmental science and pollution research international · 2021Article
- Micrococcal Nuclease stimulatesFrontiers in cellular and infection microbiology · 2021Article
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- Bacterial Biofilm Growth on 3D-Printed Materials.Frontiers in microbiology · 2021Article
- Biocompatibility and Antibacterial Properties of ZnO-Incorporated Anodic Oxide Coatings on TiZrNb Alloy.Nanomaterials (Basel, Switzerland) · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Staphylococcus aureus is commonly associated with biofilm-related infections and contributes to the large financial loss that accompany nosocomial infections. The micrococcal nuclease Nuc1 enzyme limits biofilm formation via cleavage of eDNA, a structural component of the biofilm matrix. Solid surface hydrophobicity influences bacterial adhesion forces and may as well influence eDNA production. Therefore, it is hypothesized that the impact of Nuc1 activity is dependent on surface characteristics of solid surfaces. For this reason, this study investigated the influence of solid surface hydrophobicity on S. aureus Newman biofilms where Nuc1 is constitutively produced. To this end, biofilms of both a wild-type and a nuc1 knockout mutant strain, grown on glass, salinized glass and Pluronic F-127-coated silanized glass were analysed. Results indicated that biofilms can grow in the presence of Nuc1 activity. Also, Nuc1 and solid surface hydrophobicity significantly affected the biofilm 3D-architecture. In particular, biofilm densities of the wild-type strain on hydrophilic surfaces appeared higher than of the mutant nuc1 knockout strain. Since virulence is related to bacterial cell densities, this suggests that the virulence of S. aureus Newman biofilms is increased by its nuclease production in particular on a hydrophilic surface.
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