ArticleAnnals of surgery2020
Breast Implant-associated Anaplastic Large Cell Lymphoma Incidence: Determining an Accurate Risk.
Article in Annals of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- The Risk of Breast Implant-Associated Anaplastic Large Cell Lymphoma; A Systematic Review and Meta-Analysis.Aesthetic plastic surgery · 2024Pooled it
- Implant replacement and anaplastic large cell lymphoma associated with breast implants: a quantitative analysis.Frontiers in oncology · 2023Pooled it
- Article
- Incidence of lymphomas in a nationwide prospective cohort study of breast-implanted women.Breast (Edinburgh, Scotland) · 2026Article
- Adverse Event Reports and Safety Measures for Breast Implant-associated Anaplastic Large Cell Lymphoma in Japan.Plastic and reconstructive surgery. Global open · 2026Article
- Breast implant-associated anaplastic large cell lymphoma: a case report and literature review.Frontiers in oncology · 2026Article
- Hot Topics in Implant-Based Breast Reconstruction.Journal of clinical medicine · 2025Review
- Anaplastic Large Cell Lymphoma of the Breast by Race and Ethnicity.JAMA network open · 2025Observational
- Lateral Flow Assay to Detect Carbonic Anhydrase IX in Seromas of Breast Implant-Associated Anaplastic Large Cell Lymphoma.Cancers · 2025Article
- Molecular Insights into the Diagnosis of Anaplastic Large Cell Lymphoma: Beyond Morphology and Immunophenotype.International journal of molecular sciences · 2025Review
- Unveiling the Controversy: A Literature Review on the Link Between Textured Implants and Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL).Journal of clinical medicine · 2025Review
- Current Knowledge on Breast Implant-Associated Anaplastic Large Cell Lymphoma: Evidence from Italian Ministry of Health Registry Data.Aesthetic plastic surgery · 2025Article
- Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Case Report About a Patient with Cytology Negative for Malignancy.Life (Basel, Switzerland) · 2024Article
- Current State of Evidence-Based Long-Term Monitoring Protocols for Breast Plastic Surgery Patients.Annals of surgical oncology · 2024Article
- Replacement of Shaped Textured Implants with Round Smooth Implants in Breast Reconstruction: Long-Term Outcomes.Plastic and reconstructive surgery · 2024Article
- ASO Author Reflections: Approaching BIA-ACL Diagnosis and Treatment.Annals of surgical oncology · 2024Article
- Surgical Management and Long-Term Outcomes of BIA-ALCL: A Multidisciplinary Approach.Annals of surgical oncology · 2024Article
- Management of complications following implant-based breast reconstruction: a narrative review.Annals of translational medicine · 2023Review
- Implant-based breast surgery and capsular formation: when, how and why?-a narrative review.Annals of translational medicine · 2023Review
- A Rare Case of Anaplastic Large Cell Lymphoma of the Knee Joint.Journal of orthopaedic case reports · 2023Article
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Authors and funding
19 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThis study sought to estimate the incidence and incidence rate of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) at a high-volume single institution, which enables vigorous long-term follow-up and implant tracking for more accurate estimates. SUMMARY BACKGROUND DATA: The reported incidence of BIA-ALCL is highly variable, ranging from 1 in 355 to 1 in 30,000 patients, demonstrating a need for more accurate estimates.
methodsAll patients who underwent implant-based breast reconstruction from 1991 to 2017 were retrospectively identified. The incidence and incidence rate of BIA-ALCL were estimated per patient and per implant. A time-to-event analysis was performed using the Kaplan-Meier estimator and life table.
resultsDuring the 26-year study period, 9373 patients underwent reconstruction with 16,065 implants, of which 9589 (59.7%) were textured. Eleven patients were diagnosed with BIA-ALCL, all of whom had a history of textured implants. The overall incidence of BIA-ALCL was 1.79 per 1000 patients (1 in 559) with textured implants and 1.15 per 1000 textured implants (1 in 871), with a median time to diagnosis of 10.3 years (range, 6.4-15.5 yrs). Time-to-event analysis demonstrated a BIA-ALCL cumulative incidence of 0 at up to 6 years, increasing to 4.4 per 1000 patients at 10 to 12 years and 9.4 per 1000 patients at 14 to 16 years, although a sensitivity analysis showed loss to follow-up may have skewed these estimates.
conclusionsBIA-ALCL incidence and incidence rates may be higher than previous epidemiological estimates, with incidence increasing over time, particularly in patients exposed to textured implants for longer than 10 years.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.