Evidence map›Paper›PMID 32694141›Full record

ArticlemBio2020

An Antivirulence Approach for Preventing Cryptococcus neoformans from Crossing the Blood-Brain Barrier via Novel Natural Product Inhibitors of a Fungal Metalloprotease.

Phylicia A Aaron, Kiem Vu, Angie Gelli

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. A review of the current anti-New microbes and new infections · 2026
    Review
  3. Article
  4. The Pain Is in the Brain With the Sugar-Coated Killer.The Journal of infectious diseases · 2025
    Review
  5. Diosgenin producingComputational and structural biotechnology journal · 2025
    Article
  6. Review
  7. Article
  8. Mechanisms and Virulence Factors ofJournal of fungi (Basel, Switzerland) · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Journal of fungi (Basel, Switzerland) · 2022
    Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Phylicia A AaronDepartment of Pharmacology, School of Medicine, University of California, Davis, California, USA.
Kiem VuDepartment of Pharmacology, School of Medicine, University of California, Davis, California, USA.
Angie GelliDepartment of Pharmacology, School of Medicine, University of California, Davis, California, USA acgelli@ucdavis.edu.ORCID 0000-0003-3351-0683
University of California, Davis · US

Funding

The molecular basis for the translocation of fungi from blood-to-brain.R01NS110800 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GELLI, ANGIE · 2020 to 2024
$2.3M
The role of a fungal metalloprotease in breaching the blood-brain barrierR21AI122329 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GELLI, ANGIE · 2016 to 2017
$432k
NIAID NIH HHS R21 AI122329NINDS NIH HHS R01 NS110800
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antifungal AgentsBiological ProductsBlood-Brain BarrierBrainCell LineCryptococcus neoformansFungal ProteinsHumansInhibitory Concentration 50Meningitis, CryptococcalMetalloproteasesPhytochemicalsSmall Molecule LibrariesVirulenceAntifungal AgentsBiological ProductsFungal ProteinsMetalloproteasesPhytochemicalsSmall Molecule Librariesblood-brain barriercryptococcal meningitisCryptococcus neoformanshigh throughput screenmetalloproteaseMpr1natural productsphytochemicalPichia pastoris

Identifiers

PMID32694141
PMCPMC7374060
OpenAlexW3045300654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.