ArticleReproductive biomedicine online2020
Assessment and management of the risk of SARS-CoV-2 infection in an IVF laboratory.
Article in Reproductive biomedicine online, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Healthcare Application of Failure Mode and Effect Analysis (FMEA): Is There Room in the Infectious Disease Setting? A Scoping Review.Healthcare (Basel, Switzerland) · 2025Article
- Effects of SARS-CoV-2 infection on embryological outcomes in assisted reproductive technology during the Omicron epidemic.Journal of ovarian research · 2023Article
- The actual impact of SARS-CoV-2/COVID-19 pandemic on IVF activity: a survey across Italian ART centers.Journal of assisted reproduction and genetics · 2022Article
- SARS-CoV-2 can infect human embryos.Scientific reports · 2022Article
- Risk of contamination with SARS-CoV-2 in ART.Human reproduction (Oxford, England) · 2022Article
- The impact of COVID-19 mitigation measures on fertility patients and clinics around the world.Reproductive biomedicine online · 2022Article
- Can We Cryopreserve the Sperm of COVID-19 Patients During the Pandemic?Frontiers in endocrinology · 2022Review
- Ambulatory blood pressure monitoring using telemedicine: proof-of-concept cohort and failure modes and effects analyses.Wellcome open research · 2022Article
- Human resource risk control through COVID-19 risk assessment in Indonesian manufacturing.Journal of loss prevention in the process industries · 2022Article
- Alcohol Abuse and Insomnia Disorder: Focus on a Group of Night and Day Workers.International journal of environmental research and public health · 2021Article
- Obstetric challenges during COVID-19 pandemic: A narrative review.Annals of medicine and surgery (2012) · 2021Review
- The Impact of SARS-CoV-2 on Sperm Cryostorage, Theoretical or Real Risk?Medicina (Kaunas, Lithuania) · 2021Review
- Expression map of entry receptors and infectivity factors for pan-coronaviruses in preimplantation and implantation stage human embryos.Journal of assisted reproduction and genetics · 2021Article
- A Methodology for Dynamic Assessment of Laboratory Safety by SEM-SD.International journal of environmental research and public health · 2021Article
- Infection precautions for severe acute respiratory syndrome coronavirus 2 in assisted reproduction centers: dodging an invisible bullet.Fertility and sterility · 2021Review
- Challenges in Urology during the COVID-19 Pandemic.Urologia internationalis · 2021Review
- Resuming Assisted Reproduction Services during COVID-19 Pandemic: An Initial Indian Experience.Journal of human reproductive sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
research questionThe study set out to identify corrective measures aimed at reducing the risk of aerosol-mediated viral infection within an IVF laboratory.
designA failure modes and effect analysis (FMEA) was conducted by a multidisciplinary IVF team. A schematic representation of new protocols and procedures adopted during COVID-19 emergency has been defined, including directives about the behaviour to adopt when entering the clinic and the laboratory, in case of face-to-face contact with patients and between staff members. In addition, the risk of cross-contamination between samples belonging to different patients during cell handling and manipulation has been evaluated. Potential failure modes for each phase of the emergency have been analysed, focusing on possible sources of error. Risk priority numbers have been calculated as products of Occurrence × Severity × Detection scores.
resultsExcept for cell-cell contamination, which was considered highly unlikely, failure modes during patient-staff, staff-staff and staff-cell interactions were estimated as carrrying a moderate to high risk of infection. The main corrective measures entailed precautionary logistic measures, the implementation of additional personal protective equipment and changes in the IVF laboratory procedures and scheduling of the daily routine. Some procedures were also revised, aiming to increase staff's awareness and caution.
conclusionsStandard laboratory protocols are insufficient to face a virus whose transmission is aerosol mediated. The measures outlined in this FMEA should thus be considered not only for facing this pandemic, but also for the future to promptly manage any aerosol-mediated virus infection, whose impact on the management of an IVF laboratory might be less severe than COVID-19 although not completely negligible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.