ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2020
Right single lung transplantation or double lung transplantation compared with left single lung transplantation in chronic obstructive pulmonary disease.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 26 citations in OpenAlex.
- Single versus double lung transplantation outcomes in artificial stone silicosis: a single-centre retrospective cohort study.BMJ open respiratory research · 2025Article
- Native lung aspergilloma after single lung transplantation-a case series.Journal of thoracic disease · 2025Article
- Downward hyperinflation of the native lung after right single lung transplantation for COPD: A case report highlighting diaphragmatic mobility.JHLT open · 2025Article
- Article
- Significantly reduced patient and graft survival for left vs right donor lungs for lung transplant recipients.JHLT open · 2024Article
- Management of airway complications following lung transplantation: first interventional bronchoscopy report from Türkiye.Turkish journal of medical sciences · 2024Article
- Surgical and Interventional Approaches in COPD.Respiratory care · 2023Review
- Lung transplantation for COPD/pulmonary emphysema.European respiratory review : an official journal of the European Respiratory Society · 2023Article
- Contralateral Pneumonectomy 27 Years After Right Single-Lung Transplantation for Emphysema: A Case Report.The American journal of case reports · 2022Article
- Geographic disparities in lung transplantation in the United States before and after the November 2017 allocation change.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022Article
- Comparing outcomes in patients with end-stage chronic obstructive pulmonary disease: single versus bilateral lung transplants.Interactive cardiovascular and thoracic surgery · 2021Article
- Donor quality assessment and size match in lung transplantation.Indian journal of thoracic and cardiovascular surgery · 2021Review
- Factors affecting complications development and mortality after single lung transplant.World journal of transplantation · 2021Review
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11 authors at 2 institutions in 1 country.
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Abstract
backgroundAlthough single and double lung transplantation outcomes for chronic obstructive pulmonary disease (COPD) have been investigated, right and left single lung transplants have never been rigorously compared to evaluate disease-specific differences. Single lung transplants for COPD often have hyperinflation of the contralateral native lung, which may be more pronounced in left lung transplants.
methodsUsing the United Network for Organ Sharing registry, we conducted a retrospective cohort study of 5,585 adults who underwent lung transplantation for COPD from May 4, 2005 to June 30, 2017. Subjects were followed until March 2019. Post-transplant survival was compared using Cox proportional hazards and Royston and Parmar's flexible parametric survival models. We adjusted for donor and recipient factors with known or plausible associations with survival.
resultsLung transplant recipients who received a left single lung transplant for COPD had an increased risk of post-transplant death when compared with those who received a right single lung transplant for COPD (hazard ratio [HR]: 1.24, 95% CI: 1.08-1.48, p = 0.002). Survival did not differ significantly between double lung transplant and right single lung transplant recipients (HR: 0.88, 95% CI: 0.77-1.02, p = 0.086). Adjusted 5-year survival was 57.8% (95% CI: 55.7-60.1) for double lung recipients, 56.7% (95% CI: 55.4-58.0) for right single lung recipients, and 50.9% (95% CI: 47.2-55.0) for left single lung recipients.
conclusionsIn COPD, right single lung transplantation was associated with improved post-transplant survival compared with left single lung transplantation, and no significant difference in post-transplant survival compared with double lung transplantation was found. In light of the ongoing donor lung shortage, preferential allocation of right single lungs to patients with COPD should be considered.
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