Evidence map›Paper›PMID 32693821›Full record

ArticleJournal of ovarian research2020

Bioinformatics analysis of gene expression profile of serous ovarian carcinomas to screen key genes and pathways.

Hongjun Fei, Songchang Chen, Chenming Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hongjun FeiDepartment of Reproductive Genetics, International Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai Municipal Key Clinical Specialty, Shanghai Jiao Tong University School of Medicine, No.910, Hengshan Road, Shanghai, 200030, People's Republic of China.
Songchang ChenDepartment of Reproductive Genetics, International Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai Municipal Key Clinical Specialty, Shanghai Jiao Tong University School of Medicine, No.910, Hengshan Road, Shanghai, 200030, People's Republic of China.
Chenming XuDepartment of Reproductive Genetics, International Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai Municipal Key Clinical Specialty, Shanghai Jiao Tong University School of Medicine, No.910, Hengshan Road, Shanghai, 200030, People's Republic of China. chenming_xu2006@163.com.
International Peace Maternity & Child Health Hospital · CNShanghai Jiao Tong University · CN

Funding

Regulation of Apoptosis by Mitochondrial Septins, ARTSR03TW005801 · FIC · ROCKEFELLER UNIVERSITY · PI STELLER, HERMANN · 2001 to 2003
$120k
Nosocomial Scientific Research Fund Projects from International Peace Maternity and Child Health Hospital of Shanghai Jiao Tong University School of Medicine No.GFY5801Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (CN) No.19YF1452200
6 · The paper itself

Abstract

backgroundSerous ovarian carcinomas (SCA) are the most common and most aggressive ovarian carcinoma subtype which etiology remains unclear. To investigate the prospective role of mRNAs in the tumorigenesis and progression of SCA, the aberrantly expressed mRNAs were calculated based on the NCBI-GEO RNA-seq data.

resultsOf 21,755 genes with 89 SCA and SBOT cases from 3 independent laboratories, 59 mRNAs were identified as differentially expressed genes (DEGs) (|log

conclusionsFrom all the above results, we speculate that KIF11, CDC20 and TOP2A played an important role in SCA.

Indexed as

Carcinoma, Ovarian EpithelialCdc20 ProteinsComputational BiologyCystadenocarcinoma, SerousDNA Topoisomerases, Type IIDown-RegulationFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansKinesinsOvarian NeoplasmsProspective StudiesRNA, MessengerSignal TransductionTranscriptomeCdc20 ProteinsDNA Topoisomerases, Type IIKinesinsRNA, MessengerCDC20Differentially expressed genesFunction analysisKIF11Serous ovarian carcinomasTumor biomarkers

Identifiers

PMID32693821
PMCPMC7374965
OpenAlexW3044969638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.