ArticleBiology of sex differences2020
Gender differences of morphological and hemodynamic characteristics of abdominal aortic aneurysm.
Article in Biology of sex differences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Integrated Assessment of Wall Shear Stress-Related Hemodynamic Parameters in Abdominal Aortic Aneurysms: A Retrospective Cross-Sectional Study on Ruptured Cases.International journal for numerical methods in biomedical engineering · 2026Article
- Sex-specific machine learning classification models improve outcome prediction for abdominal aortic aneurysms.Biology of sex differences · 2025Article
- Developing cardiac biomechanical models beyond the clinic: modeling stressors of daily life.Biomechanics and modeling in mechanobiology · 2025Review
- Association of aneurysm sac-specific eccentricity and abdominal aortic aneurysm rupture risk using computed tomography imaging.Quantitative imaging in medicine and surgery · 2025Article
- Cardiac digital twins: a tool to investigate the function and treatment of the diabetic heart.Cardiovascular diabetology · 2025Review
- Rapid wall shear stress prediction for aortic aneurysms using deep learning: a fast alternative to CFD.Medical & biological engineering & computing · 2025Article
- Modeling Techniques and Boundary Conditions in Abdominal Aortic Aneurysm Analysis: Latest Developments in Simulation and Integration of Machine Learning and Data-Driven Approaches.Bioengineering (Basel, Switzerland) · 2025Review
- Article
- A preliminary biomechanical study on trachea reconstruction surgery using the clavicular periosteum.Frontiers in bioengineering and biotechnology · 2023Article
- Studies Related to Ruptured Abdominal Aortic Aneurysms in the Past 10 Years (2011-2020): A Bibliometric Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2022Review
- Characteristics and Prognosis of Abdominal or Thoracic Aortic Aneurysm Patients Admitted to Intensive Care Units After Surgical Treatment: A Multicenter Retrospective Observational Study.International journal of general medicine · 2021Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundGender difference in cardiovascular diseases (CVDs) is an important topic in the field of cardiovascular medicine. In this study, we focused on the mortality difference of abdominal aortic aneurysms (AAA), which is higher for female than that of male. The aim of this study was to verify whether morphological and hemodynamic factors play their roles in this phenomenon.
methodsPatient-specific AAA models of 11 females and 23 males with similar age and body mass index (BMI) have been reconstructed based on clinical computed tomography (CT) data. Firstly, the morphological parameters (diameters, curvature, intraluminal thrombus volume, etc.) of AAA models and lumbar vertebrae models were collected and analyzed. Then, based on statistical results of morphological parameters, uniformed male and female AAA models were reconstructed, and hemodynamic simulations were conducted respectively. In post-processing, the hemodynamic performances induced by gender-different morphological geometries were analyzed and compared.
resultsThe comparison of morphological parameters revealed that the average curvature of lumbar vertebrae and AAA centerline of female AAA models were obviously higher than that of the male. The amount of intraluminal thrombus in female AAA models was relatively lower than that of the male. According to the hemodynamic simulation, the uniform female AAA model has higher peak pressure, lower oscillatory shear stress index (OSI), and lower relative residence time (RRT) than that of the male model, all of which put female AAA to a relatively higher risk hemodynamic situation.
conclusionsThe morphological and hemodynamic features of AAA have very obvious gender differences that would induce higher risk of rupture for female AAA biomechanically. These findings would help to explore the mechanism of gender differences in AAA and draw attention to gender-specific consideration for AAA treatment. More morphological and hemodynamic indictors are suggested to be involved in the future guidelines.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.