SynthesisStroke2020
Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
8.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans.Genome medicine · 2024Pooled it
- Pooled it
- Circulating MicroRNA Profiling Identifies Distinct MicroRNA Signatures in Acute Ischemic Stroke and Transient Ischemic Attack Patients.International journal of molecular sciences · 2022Trial
- Evaluation of functional annotation-informed and ancestry-specific polygenic risk scores for ischemic stroke.Frontiers in bioinformatics · 2026Article
- Advances in genetics and multi-omics for ischemic stroke: from pathogenesis to clinical translation.Frontiers in genetics · 2026Review
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Ancestry gaps in cardiovascular GWAS: a multi-database review of African representation in genomic studies.Frontiers in genetics · 2025Review
- Ancestrally diverse genome-wide association analysis highlights ancestry-specific differences in genetic regulation of plasma protein levels.medRxiv : the preprint server for health sciences · 2024Article
- Article
- Human Genetic Variation in F3 and Its Impact on Tissue Factor-Dependent Disease.Seminars in thrombosis and hemostasis · 2024Review
- Genetics in Ischemic Stroke: Current Perspectives and Future Directions.Journal of cardiovascular development and disease · 2023Review
- Evaluation of Density-Based Spatial Clustering for Identifying Genomic Loci Associated with Ischemic Stroke in Genome-Wide Data.International journal of molecular sciences · 2023Article
- Genes, environment, and African ancestry in cardiometabolic disorders.Trends in endocrinology and metabolism: TEM · 2023Review
- Multi-ancestry meta-analysis identifies 5 novel loci for ischemic stroke and reveals heterogeneity of effects between sexes and ancestries.Cell genomics · 2023Article
- A Mendelian randomization study of genetic liability to post-traumatic stress disorder and risk of ischemic stroke.Translational psychiatry · 2023Article
- Common clinical blood and urine biomarkers for ischemic stroke: an Estonian Electronic Health Records database study.European journal of medical research · 2023Article
- Does ethnicity influence dementia, stroke and mortality risk? Evidence from the UK Biobank.Frontiers in public health · 2023Article
- Comprehensive Analysis of Sideroflexin 4 in Hepatocellular Carcinoma by Bioinformatics and Experiments.International journal of medical sciences · 2023Article
- Genome-wide association study reveals the genetic determinism of serum biochemical indicators in ducks.BMC genomics · 2022Article
- Stroke-associated intergenic variants modulate a human FOXF2 transcriptional enhancer.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
48 authors at 20 institutions in 8 countries.
Keith L Keene *Department of Biology; Brody School of Medicine Center for Health Disparities, East Carolina University, Greenville, NC (K.L.K.).
Hyacinth I Hyacinth *Aflac Cancer and Blood Disorder Center of Emory University and Children's Healthcare of Atlanta University, GA (H.I.H.).
Joshua C BisUniversity of Washington, Seattle, WA (J.C.B., W.T.L.).
Steven J KittnerBaltimore Veterans Administration Medical Center and University of Maryland School of Medicine, Baltimore, MD (S.J.K., B.D.M., Y.-C.C.).
Braxton D MitchellBaltimore Veterans Administration Medical Center and University of Maryland School of Medicine, Baltimore, MD (S.J.K., B.D.M., Y.-C.C.).
Yu-Ching ChengBaltimore Veterans Administration Medical Center and University of Maryland School of Medicine, Baltimore, MD (S.J.K., B.D.M., Y.-C.C.).
Guillaume PareMcMaster University and Population Health Research Institute, Hamilton Ontario (G.P., M.C.).
Michael ChongMcMaster University and Population Health Research Institute, Hamilton Ontario (G.P., M.C.).
Martin O'DonnellNational University of Ireland Galway, Ireland (M.O.).
James F MeschiaMayo Clinic Florida, Jacksonville (J.F.M.).
Wei-Min ChenCenter for Public Health Genomics, University of Virginia, Charlottesville (W.-M.C., M.M.S., S.S.R.).
Michèle M SaleCenter for Public Health Genomics, University of Virginia, Charlottesville (W.-M.C., M.M.S., S.S.R.).
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville (W.-M.C., M.M.S., S.S.R.).
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD (M.A.N.).
Alan B ZondermanLaboratory of Epidemiology and Population Science, National Institute on Aging, Baltimore, MD (A.B.Z., M.K.E.).
Michele K EvansLaboratory of Epidemiology and Population Science, National Institute on Aging, Baltimore, MD (A.B.Z., M.K.E.).
James G WilsonUniversity of Mississippi Medical Center, Jackson (J.G.W., A.C., T.H.M.).
Adolfo CorreaUniversity of Mississippi Medical Center, Jackson (J.G.W., A.C., T.H.M.).
Hugh S MarkusUniversity of Cambridge, England, United Kingdom (H.S.M.).
Matthew TraylorWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (M.T.).
Cathryn M LewisSocial, Genetic and Developmental Psychiatry Centre, King's College London, United Kingdom (C.M.L.).
Cara L CartyInitiative for Research and Education to Advance Community Health, Washington State University, Seattle (C.L.C.).
Alexander ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (A.R., J.H., C.K.).
Jeff HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (A.R., J.H., C.K.).
Carl D LangefeldDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., C.L.).
Rebecca GottesmanJohns Hopkins University School of Medicine, Baltimore, MD (R.G.).
Thomas H MosleyUniversity of Mississippi Medical Center, Jackson (J.G.W., A.C., T.H.M.).
Daniel WooDepartment of Neurology, University of Cincinnati, OH (D.W.).
Kristine YaffeUniversity of California, San Francisco (K.Y.).
YongMei LiuDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., C.L.).
William T LongstrethUniversity of Washington, Seattle, WA (J.C.B., W.T.L.).
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle (B.M.P.).
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (A.R., J.H., C.K.).
Leslie A LangeUniversity of Colorado Anschutz Medical Campus, Denver (L.A.L.).
Ralph SaccoUniversity of Miami, Miller School of Medicine, FL (R.S., T.R.).
Tatjana RundekUniversity of Miami, Miller School of Medicine, FL (R.S., T.R.).
Jin-Moo LeeWashington University School of Medicine, St. Louis, MO (J.-M.L., C.C.).
Carlos CruchagaWashington University School of Medicine, St. Louis, MO (J.-M.L., C.C.).
Karen L FurieBrown University Warren Alpert Medical School, Providence, RI (K.L.F.).
Donna K ArnettUniversity of Kentucky, College of Public Health, Lexington (D.K.A.).
Oscar R BenaventeUniversity of British Columbia, Vancouver, (O.R.B.).
Raji P GrewalNeuroscience Institute, Saint Francis Medical Center, Trenton, NJ (R.P.G., L.R.P.).
Leema Reddy PeddareddygariNeuroscience Institute, Saint Francis Medical Center, Trenton, NJ (R.P.G., L.R.P.).
Martin DichgansInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany (M.D., R.M.).
Rainer MalikInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany (M.D., R.M.).
Bradford B WorrallDepartment of Neurology, University of Virginia, Charlottesville (B.B.W.).
Myriam FornageBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston (M.F.).
COMPASS, SiGN, and METASTROKE Consortia
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAUniversity of Maryland, Baltimore · USUniversity of Mississippi Medical Center · USUniversity of Virginia · USLMU Klinikum · DENational Institute on Aging · USPopulation Health Research Institute · CASt. Francis Medical Center · USUniversity of Miami · USUniversity of Washington · USWake Forest University · USWashington University in St. Louis · USBrown Foundation · USBrown University · USCarnegie Institution for Science · USChildren's Healthcare of Atlanta · USData Tecnica International (United States) · USEast Carolina University · USJacksonville College · USJohns Hopkins University · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MVCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MQAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MVitamin Intervention for Stroke Prevention (VISP)R01NS034447 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI TOOLE, JAMES F · 1996 to 2006
$18.0MResearch BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MIntramural NIH HHS Z01 AG000513Intramural NIH HHS Z01 AG000954Medical Research Council G9521010Medical Research Council MC_EX_MR/M009203/1Medical Research Council MC_PC_14089Medical Research Council MR/M009203/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR003098NCRR NIH HHS UL1 RR025005NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004436NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG005160NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL138423NHLBI NIH HHS R56 HL136210NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL117721NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK072488NIDDK NIH HHS R01 DK084350NIMHD NIH HHS HHSN268201800013INIMHD NIH HHS L60 MD013112NINDS NIH HHS R01 NS034447NINDS NIH HHS R01 NS039987NINDS NIH HHS R01 NS042733NINDS NIH HHS R01 NS045012NINDS NIH HHS R01 NS085419NINDS NIH HHS R01 NS105150NINDS NIH HHS U01 NS041588NINDS NIH HHS U01 NS069208NINDS NIH HHS U24 NS107222NINDS NIH HHS U24 NS107230WHI NIH HHS N01 WH022110
Abstract
background and purposeStroke is a complex disease with multiple genetic and environmental risk factors. Blacks endure a nearly 2-fold greater risk of stroke and are 2× to 3× more likely to die from stroke than European Americans.
methodsThe COMPASS (Consortium of Minority Population Genome-Wide Association Studies of Stroke) has conducted a genome-wide association meta-analysis of stroke in >22 000 individuals of African ancestry (3734 cases, 18 317 controls) from 13 cohorts.
resultsIn meta-analyses, we identified one single nucleotide polymorphism (rs55931441) near the
conclusionsThese findings represent the most thorough investigation of genetic determinants of stroke in individuals of African descent, to date.
Indexed as
Black or African AmericanCohort StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotideStrokebrain ischemiacoronary artery diseasegenome-wide association studymeta-analysisphenotyperisk factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.