Evidence map›Paper›PMID 32693739›Full record

ArticleInternational journal of STD & AIDS2020

They are likely to be there: using a family-centered index testing approach to identify children living with HIV in Kenya.

Nicollate Okoko, Jayne L Kulzer, Kristen Ohe, Margaret Mburu, Hellen Muttai, Lisa L Abuogi, Elizabeth A Bukusi, Craig R Cohen, Jeremy Penner

Open access · greenAbstract read
In one paragraph

Article in International journal of STD & AIDS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Nicollate OkokoCentre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Jayne L KulzerDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-3314-9891
Kristen OheSchool of Medicine, University of Colorado, Denver, CO, USA.
Margaret MburuDepartment of Global Health, University of Washington, Seattle, WA, USA.
Hellen MuttaiDivision of Global HIV/AIDS, U.S. Centers for Disease Control and Prevention, Nairobi, Kenya.
Lisa L AbuogiDepartment of Pediatrics, University of Colorado, Aurora, CO, USA.
Elizabeth A BukusiCentre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Craig R CohenDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Jeremy PennerUniversity of British Columbia, Vancouver, Canada.
Kenya Medical Research Institute · KEUniversity of California, San Francisco · USCenters for Disease Control and Prevention · KEUniversity of British Columbia · CAUniversity of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · USUniversity of Washington · US

Funding

SUPPORTING THE IMPLEMENTATION AND EXPANSION OF HIGH QUALITY HIVU2GPS001913 · PS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COHEN, CRAIG R · 2010 to 2016
$57.6M
CGH CDC HHS NU2GGH001947NCHHSTP CDC HHS U2G PS001913PEPFAR NU2GGH001947
6 · The paper itself

Abstract

In Kenya, only half of children with a parent living with HIV have been tested for HIV. The effectiveness of family-centered index testing to identify children (0-14 years) living with HIV was examined. A retrospective record review was conducted among adult index patients newly enrolled in HIV care between May and July 2015; family testing, results, and linkage to treatment outcomes were followed through May 2016 at 60 high-volume clinics in Kenya. Chi square test compared yield (percentage of HIV tests positive) among children tested through family-centered index testing, outpatient and inpatient testing. Review of 1937 index client charts led to 3005 eligible children identified for testing. Of 2848 (94.8%) children tested through family-centered index testing, 127 (4.5%) had HIV diagnosed, 100 (78.7%) were linked to care, and 85 of those eligible (91.4%) initiated antiretroviral therapy (ART).Family testing resulted in higher yield compared to inpatient (1.8%, p < 0.001) or outpatient testing (1.6%, p < 0.001). The absolute number of children living with HIV identified was highest with outpatient testing. The relative contribution of testing approach to total children identified with HIV was outpatient testing (69%), family testing (26%), and inpatient testing (5%). The family testing approach demonstrated promise in achieving the first two "90s" (identification and ART initiation) of the 90-90-90 targets for children, with additional effort required to improve linkage from testing to treatment.

Indexed as

AdolescentAnti-HIV AgentsChildChild, PreschoolFamily CharacteristicsFemaleHIV InfectionsHumansInfantInfant, NewbornKenyaMaleMass ScreeningRetrospective StudiesAnti-HIV AgentsAfricadiagnosisHIVscreeningtreatment

Identifiers

PMID32693739
PMCPMC7530071
OpenAlexW3044808706

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.