Evidence map›Paper›PMID 32693712›Full record

ArticleAutophagy2021

PtdIns4P restriction by hydrolase SAC1 decides specific fusion of autophagosomes with lysosomes.

Hongjun Zhang, Jiao Zhou, Peng Xiao, Yong Lin, Xin Gong, Shiyan Liu, Qingjia Xu, Minjin Wang, Haiyan Ren, Mengji Lu and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Hongjun ZhangDepartment of Neurosurgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Jiao ZhouDepartment of Neurosurgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Peng XiaoDepartment of Neurology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Yong LinKey Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China.
Xin GongDepartment of Respiratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Shiyan LiuDepartment of Neurosurgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Qingjia XuDepartment of Neurosurgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Minjin WangDepartment of Clinical Laboratory, West China Hospital, Sichuan University, Chengdu, China.
Haiyan RenDepartment of Respiratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Mengji LuInstitute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Yuan WangDepartment of Neurology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0002-6324-6134
Jing ZhuState Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Zhiping XieState Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0001-5816-6159
Huihui LiWest China Second University Hospital, Sichuan University, Chengdu, China.
Kefeng LuDepartment of Neurosurgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0001-8200-9380
Sichuan University · CNShanghai Jiao Tong University · CNChongqing Medical University · CNUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biogenesis of autophagosomes is the early step of macroautophagy/autophagy and requires membrane acquisition mainly from ER-Golgi-sourced precursor vesicles. Matured autophagosomes fuse with lysosomes for final degradation. However, how this selective fusion is determined remains elusive. Here, we identified Sac1 by a high throughput screen in

Indexed as

AutophagosomesAutophagyEndoplasmic ReticulumGolgi ApparatusHeLa CellsHumansHydrolasesLysosomesMembrane FusionPhosphatidylinositol PhosphatesPhosphoric Monoester HydrolasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsHydrolasesphosphatidylinositol 4-phosphatePhosphatidylinositol PhosphatesPhosphoric Monoester HydrolasesSAC1 protein, S cerevisiaeSaccharomyces cerevisiae Proteinsautophagosome-lysosome fusionERGolgiPtdIns4PSac1

Identifiers

PMID32693712
PMCPMC8386628
OpenAlexW3044415831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.