ArticlePLoS neglected tropical diseases2020
A clinical scoring system to predict long-term arthralgia in Chikungunya disease: A cohort study.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Clinical manifestations associated with the chronic phase of Chikungunya Fever: A systematic review of prevalence.PLoS neglected tropical diseases · 2025Pooled it
- Characterization of the clinical forms of chronic chikungunya: an observational cohort study in Rio de Janeiro.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026Observational
- Identification of multiple arbovirus infections/exposure in Northeastern Brazil using a multiplex microsphere immunoassay.Journal of clinical microbiology · 2026Article
- Predictors of chronic arthralgia following chikungunya virus infection.GMS hygiene and infection control · 2026Article
- Identification of a TCR signature in peripheral blood derived CD4+ T cells, associated with chronic chikungunya disease, suggests a conducive, female-biased, background immune profile.Frontiers in immunology · 2026Article
- A Roadmap Towards the Identification and Validation of Conserved T Cell Epitope Regions in Viral Pathogen Families with Pandemic Potential.Current pharmaceutical biotechnology · 2026Article
- Hospitalisation, mortality and years of life lost among chikungunya and dengue cases in Brazil: a nationwide cohort study, 2015-2024.Lancet regional health. Americas · 2025Article
- The possibly neglected victims: Re-examining the involvement of children in the chikungunya epidemic.Pediatric investigation · 2025Article
- Systematic Review of the Ovitrap Surveillance ofTropical medicine and infectious disease · 2025Review
- Chikungunya in a pediatric cohort: Asymptomatic infection, seroconversion, and chronicity rates.PLoS neglected tropical diseases · 2025Article
- Nomogram for the prediction of relapse factors in patients with neuromyelitis optica spectrum disorder during rituximab treatment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Pathophysiology of chikungunya virus infection associated with fatal outcomes.Cell host & microbe · 2024Article
- Chikungunya virus antepartum transmission and abnormal infant outcomes in a cohort of pregnant women in Nigeria.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024Article
- Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas.Viruses · 2023Article
- Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort.PLoS neglected tropical diseases · 2023Article
- Citywide Integrated Aedes aegypti Mosquito Surveillance as Early Warning System for Arbovirus Transmission, Brazil.Emerging infectious diseases · 2022Review
- Post-chikungunya arthritis: a longitudinal study in a tertiary care hospital in Bangladesh.Tropical medicine and health · 2022Article
- Entomo-virological surveillance followed by serological active survey of symptomatic individuals is helpful to identify hotspots of early arbovirus transmission.Frontiers in public health · 2022Article
- Arthralgia resolution rate following chikungunya virus infection.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Review
- Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis.Scientific reports · 2021Article
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Authors and funding
20 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChikungunya virus (CHIKV) has caused worldwide epidemics that impose a major burden on health systems. Approximately half of infected individuals develop chronic debilitating arthralgia, affecting their quality of life. Here, we identified the relevant clinical and demographic variables in the acute phase of CHIKV infection prospectively linked to chronic arthralgia to elaborate a prognostic scoring system.
methodsAcute CHIKV infection cases (n = 134) confirmed by serology or molecular test were examined <10 days of disease onset and followed for one year to evaluate for disease progression. Potential risk factors for chronic arthralgia were evaluated by multivariate analysis to develop a prognostic scoring system, which was subsequently tested in an independent validation cohort consisting of 42 individuals.
resultsA total of 107 out of 134 (80%) acute CHIKV-confirmed cases from the derivation cohort were re-examined one year after enrollment. Chronic arthralgia post-CHIKV infection was diagnosed in 64 (60%). Five of the 12 parameters evaluated in the acute phase were statistically associated with persistent arthralgia and were further tested by Bayesian analysis. These variables were weighted to yield a prognosis score denominated SHERA (Sex, Hypertension, Edema, Retroocular pain, Age), which exhibited 81.3% accuracy in predicting long-term arthralgia post-CHIKV infection in the derivation cohort, and 76.5% accuracy in the validation cohort.
conclusionsThe simplified and externally validated prognostic scoring system, SHERA, is a useful method to screen acutely CHIKV-infected patients at elevated risk of chronic arthralgia who will benefit from specific interventions. This tool could guide public health policies, particularly in resource-constrained settings.
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