ReviewEuropean journal of medicinal chemistry2020
COVID-19 treatment: Much research and testing, but far, few magic bullets against SARS-CoV-2 coronavirus.
Review in European journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- A Mini Review on Metal Complexes as Potential Anti-SARS-CoV-2 Agents: Insights from Molecular Docking Studies.Mini reviews in medicinal chemistry · 2026Review
- Synthesis, biological and computational studies of flavonoid acetamide derivatives.RSC advances · 2022Article
- Leukotriene inhibitors with dexamethasone show promise in the prevention of death in COVID-19 patients with low oxygen saturations.Journal of clinical and translational science · 2022Article
- Factors Associated with COVID-19 Vaccine Hesitancy in Korea.Chonnam medical journal · 2022Article
- Biology of COVID-19 and related viruses: Epidemiology, signs, symptoms, diagnosis, and treatment.Best practice & research. Clinical anaesthesiology · 2021Review
- Insights into forsythia honeysuckle (Lianhuaqingwen) capsules: A Chinese herbal medicine repurposed for COVID-19 pandemic.Phytomedicine plus : international journal of phytotherapy and phytopharmacology · 2021Review
- Metal-Promoted Heterocyclization: A Heterosynthetic Approach to Face a Pandemic Crisis.Molecules (Basel, Switzerland) · 2021Review
- The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2.European journal of medicinal chemistry · 2021Review
- N-terminally truncated nucleocapsid protein of SARS-CoV-2 as a better serological marker than whole nucleocapsid protein in evaluating the immunogenicity of inactivated SARS-CoV-2.Journal of medical virology · 2021Article
- Medicines and illusions in the fight against COVID-19 in Brazil.Ethics, medicine, and public health · 2021Article
- Circulating Levels of Calcitonin Gene-Related Peptide Are Lower in COVID-19 Patients.Journal of the Endocrine Society · 2021Article
- Optimization in the Context of COVID-19 Prediction and Control: A Literature Review.IEEE access : practical innovations, open solutions · 2021Article
- Drug repurposing of dermatologic medications to treat coronavirus disease 2019: Science or fiction?Clinics in dermatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The new virus of the of β-Coronaviruses genus, SARS-CoV-2, is the causative agent of coronavirus disease-2019 (COVID-19) and is winning a proverbial chess match against all players simultaneous, including physicians, clinicians, pathologists, doctors, scientists, economists, athletes and politicians. The COVID-19 outbreak has seriously threatened public health, killing the most vulnerable persons and causing general panic. To stop this disease, effective remedies (i.e., drugs, vaccines, personal protection elements, etc.) are urgently required. Unfortunately, no registered specific therapies (including antiviral therapies, immune-modulating agents and vaccines) are currently available to treat coronavirus infections, highlighting an urgent need for therapeutics targeting SARS-CoV-2. In this work, fourteen existing small molecule drugs or/and experimental drugs selected by experts and examined from the point of view of bioavailability via the Lipinski-Veber rules and assessment of their physicochemical descriptors. The aim of this study is to discover selected pattern similarities and peculiar characteristics that could be useful for antiviral drug optimization, drug combination or new antiviral agent design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.