Evidence map›Paper›PMID 32692933›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

Functional Genomics of

Jennifer A Wambach, Ping Yang, Daniel J Wegner, Hillary B Heins, Cliff Luke, Fuhai Li, Frances V White, F Sessions Cole

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00014859 (Epidemiology of Surfactant Protein-B Deficiency), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00014859 completednot on this map

Epidemiology of Surfactant Protein-B Deficiency

Typeobservational_patient_registrySponsorWashington University School of MedicineRan2001 to 2024Enrolled5,176ConditionsLung Diseases, Respiratory Distress Syndrome, Newborn, Pulmonary Surfactant, Lung Diseases, Interstitial
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 27 citations in OpenAlex.

  1. Lentiviral-mediated gene complementation to rescue pathogenic ABCA3 variants.American journal of respiratory cell and molecular biology · 2026
    Article
  2. Article
  3. Article
  4. Lentiviral-mediated gene complementation rescues pathogenicbioRxiv : the preprint server for biology · 2025
    Article
  5. Respirology case reports · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. THERAPIES FOR NEONATAL DISEASES OF THE SURFACTANT SYSTEM.Transactions of the American Clinical and Climatological Association · 2025
    Review
  10. Biomedicines · 2024
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Quantifying Functional Impairment ofInternational journal of molecular sciences · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. First Steps toward Personalized Therapies for ABCA3 Deficiency.American journal of respiratory cell and molecular biology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Jennifer A WambachEdward Mallinckrodt Department of Pediatrics.ORCID 0000-0002-9299-0499
Ping YangEdward Mallinckrodt Department of Pediatrics.
Daniel J WegnerEdward Mallinckrodt Department of Pediatrics.
Hillary B HeinsEdward Mallinckrodt Department of Pediatrics.
Cliff LukeEdward Mallinckrodt Department of Pediatrics.
Fuhai LiEdward Mallinckrodt Department of Pediatrics.
Frances V WhiteDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
F Sessions ColeEdward Mallinckrodt Department of Pediatrics.
Mallinckrodt (Ireland) · IEInstitute for Medical Informatics and Biostatistics · CHWashington University in St. Louis · US

Funding

Functional Characterization of ABCA3 Genomic VariantsR01HL149853 · NHLBI · WASHINGTON UNIVERSITY · PI Jennifer Wambach · 2020 to 2026
$3.9M
Lipidomic Screening For Functional Surfactant Gene MutationsR33HL120760 · NHLBI · WASHINGTON UNIVERSITY · PI COLE, FRANCIS SESSIONS · 2016 to 2018
$1.4M
Lipidomic Screening For Functional Surfactant Gene MutationsR21HL120760 · NHLBI · WASHINGTON UNIVERSITY · PI COLE, FRANCIS SESSIONS · 2014 to 2015
$441k
NHLBI NIH HHS R01 HL149853NHLBI NIH HHS R21 HL120760NHLBI NIH HHS R33 HL120760
6 · The paper itself

Abstract

Rare or private, biallelic variants in the

Indexed as

A549 CellsAdenosine TriphosphatasesAlveolar Epithelial CellsATP-Binding Cassette TransportersCell Line, TumorCRISPR-Cas SystemsDNA, ComplementaryFluorescent Antibody TechniqueGene EditingGenomeGenomicsHumansLungLung Diseases, InterstitialMutation, MissenseABCA3 protein, humanAdenosine TriphosphatasesATP-Binding Cassette TransportersDNA, ComplementaryABCA3ATP-binding cassette subfamily A member 3childhood interstitial lung diseaseneonatal respiratory distress syndromesurfactant

Identifiers

PMID32692933
PMCPMC7528924
OpenAlexW3044369335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.