ArticleClinical and translational science2021
Exocrine Pancreatic Dysfunction Increases the Risk of New-Onset Diabetes Mellitus: Results of a Nationwide Cohort Study.
Article in Clinical and translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- The Metabolic Legacy of Acute Pancreatitis: Post-Pancreatitis Diabetes Mellitus.Clinical and experimental gastroenterology · 2026Review
- Tumor necrosis factor-α promotes abnormal glucose metabolism after acute pancreatitis by inducing islet β-cell apoptosisWorld journal of gastroenterology · 2025Article
- Individualized prediction of post-acute pancreatitis diabetes mellitus by combining lipid metabolism and anatomical features.Insights into imaging · 2025Article
- Risk Factors and Mechanisms for Diabetes in Pancreatitis.Gastroenterology clinics of North America · 2025Review
- Incidence of pancreatic exocrine insufficiency and efficacy of pancreatic enzyme replacement therapy in acute pancreatitis patients.American journal of translational research · 2025Article
- Healthcare disparities in pancreatitis: knowledge gaps and next steps.Current opinion in gastroenterology · 2024Review
- A novel clinical model for risk prediction and stratification of new-onset diabetes mellitus after distal pancreatectomy.Hepatobiliary surgery and nutrition · 2023Article
- Diabetes as a consequence of acute pancreatitis.World journal of gastroenterology · 2023Review
- Diabetes mellitus as a consequence of acute severe pancreatitis: Unraveling the mystery.World journal of diabetes · 2023Review
- Post-acute pancreatitis diabetes: A complication waiting for more recognition and understanding.World journal of gastroenterology · 2023Review
- The Cause and Effect Relationship of Diabetes after Acute Pancreatitis.Biomedicines · 2023Review
- Association of pancreatitis with risk of diabetes: analysis of real-world data.Frontiers in clinical diabetes and healthcare · 2023Article
- Post-pancreatitis diabetes mellitus: insight on optimal management with nutrition and lifestyle approaches.Annals of medicine · 2022Review
- Colloidal lithography as a novel approach for the development of Ni-nanocavity insulin sensor.Scientific reports · 2022Article
- Relationship between Habitual Intake of Vitamins and New-Onset Prediabetes/Diabetes after Acute Pancreatitis.Nutrients · 2022Article
- Associations between Intra-Pancreatic Fat Deposition, Pancreas Size, and Pancreatic Enzymes in Health and after an Attack of Acute Pancreatitis.Obesity facts · 2022Article
- Diabetes following acute pancreatitis.The lancet. Gastroenterology & hepatology · 2021Review
- Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review.Pancreas · 2021Review
- Pancreatitis, Pancreatic Cancer, and Their Metabolic Sequelae: Projected Burden to 2050.Clinical and translational gastroenterology · 2020Article
- Chronic Pancreatitis Is Characterized by Elevated Circulating Periostin Levels Related to Intra-Pancreatic Fat Deposition.Journal of clinical medicine research · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well established that individuals with diabetes mellitus (DM) may develop exocrine pancreatic dysfunction (EPD) requiring pancreatic enzyme replacement therapy, whereas the converse relationship has been poorly studied. Pancreatitis is a disease that is well suited to investigate the latter as it is often characterized by the development of EPD and/or new-onset DM. The aim was to investigate the association between EPD and the risk of new-onset DM in individuals after the first attack of pancreatitis. Using nationwide pharmaceutical dispensing data and hospital discharge data, this cohort study included a total of 9,124 post-pancreatitis individuals. EPD was defined as having two or more dispensing records of pancreatic enzymes. Considering EPD as a time-dependent variable, multivariable Cox regression analysis was conducted. A 1-year lag period between EPD and DM was introduced to minimize reverse causality. Age, sex, ethnicity, alcohol consumption, tobacco smoking, social deprivation index, Charlson comorbidity index, and use of proton pump inhibitors were adjusted for. In the overall cohort, EPD was associated with a significantly higher risk for new-onset DM (adjusted hazard ratio, 3.83; 95% confidence interval, 2.37-6.18). The association remained statistically significant when a 1-year lag period was applied (adjusted hazard ratio, 2.51; 95% confidence interval, 1.38-4.58), as well as when the analysis was constrained to mild acute pancreatitis (4.65; 2.18-9.93). The findings suggest that individuals with EPD, even those without extensive mechanistic destruction of the pancreas, are at an increased risk for new-onset DM. Purposely designed studies are warranted to investigate mechanisms behind the association and if the mechanisms could be targeted therapeutically.
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