ArticlePloS one2020
Photoprotective effect of Astragalus membranaceus polysaccharide on UVA-induced damage in HaCaT cells.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Transcriptomic Responses ofInternational journal of molecular sciences · 2026Article
- Interdisciplinarity traditional Chinese medicine microneedles in skin disease treatment: Recent advances and challenges.Bioactive materials · 2026Review
- What Are Topical Adaptogens? A Systematic Review and Proposed System to Identify and Categorize Skin Adaptogens in Dermatology.The Journal of clinical and aesthetic dermatology · 2025Article
- Structural Characterization and Anti-Ultraviolet Radiation Damage Activity of Polysaccharides fromMolecules (Basel, Switzerland) · 2025Article
- Astragalus Membranaceus-Can It Delay Cellular Aging?Nutrients · 2025Review
- UVB-induced HaCat cell damage and Myricaria Paniculata's molecular effects.Scientific reports · 2025Article
- Medicinal Plant Extracts Targeting UV-Induced Skin Damage: Molecular Mechanisms and Therapeutic Potential.International journal of molecular sciences · 2025Review
- Article
- Protective Effects of Pear Extract on Skin from In Vitro and In Vivo UVA-Induced Damage.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Advances in research on the anti-tumor mechanism ofFrontiers in oncology · 2024Review
- Exploring Natural Products as Radioprotective Agents for Cancer Therapy: Mechanisms, Challenges, and Opportunities.Cancers · 2023Review
- Characterization and antibacterial behavior of an edible konjac glucomannan/soluble black tea powder hybrid film with ultraviolet absorption.RSC advances · 2022Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe skin provides a predominant barrier against chemical, physical and microbial incursion. The intemperate exposure to ultraviolet A (UVA) radiation can cause excessive cellular oxidative stress, leading to skin damage, proteins damage and mitochondrial dysfunction. There is sufficient evidences supporting the proposal that mitochondria is highly implicated in skin photo-damage.
methodsIn the present study, a polysaccharide isolated from Astragalus membranaceus was further purified to be an α-glucan, which was further investigated its beneficial influence on UVA-induced photo-damage in HaCaT cells.
resultsOur results showed that the purified Astragalus membranaceus polysaccharide (AP) can protect HaCaT cells from UVA-induced photo-damage through reducing UVA-induced intracellular ROS production and mitochondrial membrane potential, thereby altering ATP content. It was found that the UVA induced damage in HaCaT cells could be effectively restored by co-treatment with AP.
conclusionsAP exhibited promising potential for advanced application as multifunctional skin care products and drugs.
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