Evidence map›Paper›PMID 32692580›Full record

ReviewAnnals of the American Thoracic Society2020

Repurposing Existing Drugs for the Treatment of COVID-19.

Hugo Farne, Kartik Kumar, Andrew I Ritchie, Lydia J Finney, Sebastian L Johnston, Aran Singanayagam

Abstract readReview
In one paragraph

Review in Annals of the American Thoracic Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Debate on mandatory COVID-19 vaccination.Ethics, medicine, and public health · 2022
    Article
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  7. Article
  8. Review
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hugo FarneNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0003-2556-3953
Kartik KumarNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Andrew I RitchieNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Lydia J FinneyNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Sebastian L JohnstonNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Aran SinganayagamNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0001-9849-0033

Funding

Medical Research Council MR/V000098/1
6 · The paper itself

Abstract

The rapid global spread and significant mortality associated with the coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection has spurred an urgent race to find effective treatments. Repurposing existing drugs is a particularly attractive approach as pharmacokinetic and safety data already exist; thus, development can leapfrog straight to clinical trials of efficacy, generating results far more quickly than

Indexed as

Coronavirus InfectionsPandemicsPneumonia, ViralAnti-Inflammatory AgentsAntiviral AgentsBetacoronavirusCOVID-19COVID-19 Drug TreatmentDrug DiscoveryDrug RepositioningHumansImmunologic FactorsPatient SelectionSARS-CoV-2Anti-Inflammatory AgentsAntiviral AgentsImmunologic FactorscoronavirusCOVID-19severe acute respiratory syndrome coronavirus 2therapeutics

Identifiers

PMID32692580
PMCPMC7640626

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.