Evidence map›Paper›PMID 32692536›Full record

ArticleACS infectious diseases2020

Pharmacological Characterization of the Mechanism of Action of

Chunlong Ma, Yanmei Hu, Jiantao Zhang, Jun Wang

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 28 citations in OpenAlex.

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  12. Enterovirus A71 antivirals: Past, present, and future.Acta pharmaceutica Sinica. B · 2022
    Article
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  15. TheEmerging microbes & infections · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chunlong MaDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 E. Mabel Street, Tucson, Arizona 85721, United States.
Yanmei HuDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 E. Mabel Street, Tucson, Arizona 85721, United States.
Jiantao ZhangDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 E. Mabel Street, Tucson, Arizona 85721, United States.
Jun WangDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 E. Mabel Street, Tucson, Arizona 85721, United States.ORCID 0000-0002-4845-4621
University of Arizona · US

Funding

Drug target validation of the enterovirus D68 2A proteaseR01AI157046 · NIAID · UNIVERSITY OF ARIZONA · PI WANG, JUN · 2020 to 2024
$3.4M
High Throughput Screening of Inhibitors Targeting the Enterovirus A71 and D68 2A ProteasesR01AI147325 · NIAID · UNIVERSITY OF ARIZONA · PI WANG, JUN · 2019 to 2022
$1.7M
Drug Discovery Targeting the Influenza A Virus M2-S31N Proton ChannelR33AI119187 · NIAID · UNIVERSITY OF ARIZONA · PI PEREZ, DANIEL R, WANG, JUN · 2017 to 2019
$1.2M
Drug Discovery Targeting the Influenza A Virus M2-S31N Proton ChannelR21AI119187 · NIAID · UNIVERSITY OF ARIZONA · PI PEREZ, DANIEL R, WANG, JUN · 2015 to 2016
$419k
Discovery of broad-spectrum influenza antivirals with a high genetic barrier to drug resistance by targeting the viral polymeraseR21AI144887 · NIAID · UNIVERSITY OF ARIZONA · PI WANG, JUN · 2019 to 2020
$415k
NIAID NIH HHS R01 AI147325NIAID NIH HHS R01 AI157046NIAID NIH HHS R21 AI119187NIAID NIH HHS R21 AI144887NIAID NIH HHS R33 AI119187
6 · The paper itself

Abstract

Enterovirus D68 (EV-D68) is a re-emerging virus that causes moderate to severe respiratory diseases in children. In severe cases, EV-D68 infection can lead to neurological complications called acute flaccid myelitis (AFM). There is currently no antiviral or vaccine available for EV-D68. The goal of this study is to delineate the mechanism of action of a promising antiviral drug candidate

Indexed as

Central Nervous System Viral DiseasesEnterovirus D, HumanEnterovirus InfectionsMyelitisAntiviral AgentsChildHumansAntiviral Agents2CantiviralEnterovirus D68R523062resistance

Identifiers

PMID32692536
PMCPMC8057299
OpenAlexW3044118569

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.