ArticleThe Journal of nutrition2020
Soy Intake and Colorectal Cancer Risk: Results from a Pooled Analysis of Prospective Cohort Studies Conducted in China and Japan.
Article in The Journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Dietary factors and colorectal cancer risk in Asian populations: a systematic review and meta-analysis of cohort studies.Cancer causes & control : CCC · 2025Pooled it
- Nuts and legumes consumption and risk of colorectal cancer: a systematic review and meta-analysis.European journal of epidemiology · 2022Pooled it
- Association of Legume Intake with Incident Hyperuricemia: A Prospective Cohort Study in Shanghai Adult Residents.Nutrients · 2026Article
- Associations between dietary protein intake and liver cancer risk: findings from two population-based cohorts in China.BMC public health · 2025Article
- A cross-sectional study of dietary and urinary soy isoflavones about coal-burning fluorosis in Guizhou, China.Frontiers in nutrition · 2025Article
- The effect of healthy eating on the development of stomach and colorectal cancer by the smoking and drinking status: Results from the Korean National Cancer Center (KNCC) community cohort study.Cancer medicine · 2024Article
- Equol: a metabolite of gut microbiota with potential antitumor effects.Gut pathogens · 2024Review
- Association of soy intake and cooking methods with colorectal polyp and adenoma prevalence: findings from the extended Lanxi pre-colorectal cancer cohort (LP3C).Frontiers in nutrition · 2024Article
- The Role of Choline, Soy Isoflavones, and Probiotics as Adjuvant Treatments in the Prevention and Management of NAFLD in Postmenopausal Women.Nutrients · 2023Review
- Diet is Linked to Colorectal Cancer Risk among Asian Adults: A Scoping Review.The Malaysian journal of medical sciences : MJMS · 2023Article
- Soy Intake and Risk of Type 2 Diabetes Among Japanese Men and Women: JACC Study.Frontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundSoy is commonly consumed in east Asian countries and is suggested to reduce colorectal cancer (CRC) risk. However, results from epidemiologic studies are inconsistent, despite the anti-inflammatory and antiproliferative properties of soy isoflavones and soy protein.
objectiveWe evaluated the association between soy isoflavones and soy protein and CRC risk using 4 prospective cohort studies from China and Japan.
methodsData were pooled from the Shanghai Women's Health Study (SWHS), Shanghai Men's Health Study (SMHS), Japan Public Health Center-based Prospective Study Cohort 1 (JPHC1), and Cohort 2 (JPHC2). Cox proportional hazards models estimated HRs and corresponding 95% CIs for the association of soy protein and isoflavone intake with CRC risk. The study included 205,060 individuals, among whom 2971 were diagnosed with incident CRC over an average follow-up of 12.7 y.
resultsNo statistically significant associations with CRC risk were observed for soy protein or isoflavone intake. No association was observed among ever smokers consuming higher isoflavones (HRisoflavones: 0.83; 95% CI: 0.68, 1.00) and soy protein (HRsoy protein: 0.81; 95% CI: 0.39, 1.10). However, risk reductions were observed among premenopausal women with a body mass index [BMI (kg/m2)] <23.0 at baseline for higher isoflavone (HRisoflavones: 0.58, 95% CI: 0.34, 0.98).
conclusionsNo evidence for an overall reduction in CRC risk by increasing soy food intake (i.e., protein or isoflavones) was observed. However, the association between soy and CRC risk may vary by BMI, smoking, and menopausal status among women. Future investigations are needed to further understand the biologic mechanisms observed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.