ArticleEnvironmental health perspectives2020
Occupational Pesticide Use and Risk of Renal Cell Carcinoma in the Agricultural Health Study.
Article in Environmental health perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Review
- Atrazine use and markers of kidney function and nephrotoxicity among male farmers in the Biomarkers of Exposure and Effect in Agriculture Study.Occupational and environmental medicine · 2025Article
- Trends in urinary tract cancer incidence in Golestan province, Iran: a 16-year population-based study.BMC cancer · 2025Article
- Imbalance of human CD4Archives of toxicology · 2025Article
- Risk factors for kidney cancer and socio-occupational category: significant impact of chlorinated solvents (UroCCR 111).World journal of urology · 2024Article
- Exposure to Pesticides and Breast Cancer in an Agricultural Region in Brazil.Environmental science & technology · 2024Article
- An Updated Evaluation of Atrazine-Cancer Incidence Associations among Pesticide Applicators in the Agricultural Health Study Cohort.Environmental health perspectives · 2024Article
- Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned.Environmental health perspectives · 2023Review
- The Hematological and Biochemical Effects from Pesticide Exposure on Thai Vegetable Farmers.Toxics · 2023Article
- Review
- Safety Measures, Pesticide Concerns and Resources Utilized among Young Adult Workers: A Brief Report.Journal of agromedicine · 2023Article
- Atrazine Toxicity: The Possible Role of Natural Products for Effective Treatment.Plants (Basel, Switzerland) · 2023Review
- How Does Environmental and Occupational Exposure Contribute to Carcinogenesis in Genitourinary and Lung Cancers?Cancers · 2023Review
- Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward.International journal of cancer · 2023Article
- Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated.Frontiers in public health · 2023Article
- Review
- Pesticide use and kidney function among farmers in the Biomarkers of Exposure and Effect in Agriculture study.Environmental research · 2021Article
- Educating the public about toxic chemicals that we unknowingly consume: A potential important role for the practicing pharmacists.Journal of the American Pharmacists Association : JAPhAReview
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAgricultural work and occupational pesticide use have been associated with increased risk of renal cell carcinoma (RCC), the most common form of kidney cancer. However, few prospective studies have investigated links to specific pesticides.
objectiveWe evaluated the lifetime use of individual pesticides and the incidence of RCC.
methodsWe evaluated the associations between intensity-weighted lifetime days (IWDs) of 38 pesticides and incident RCC in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in Iowa and North Carolina. Among 55,873 applicators, 308 cases were diagnosed between enrollment (1993-1997) and the end of follow-up (2014-2015). We estimated incidence rate ratios (RRs) and 95% confidence intervals (CIs) using Poisson regression, controlling for potential confounding factors, with lagged and unlagged pesticide exposures.
resultsThere was a statistically significant increased risk of RCC among the highest users of 2,4,5-T compared with never users [unlagged
conclusionsThis is, to our knowledge, the first prospective study to evaluate RCC risk in relation to various pesticides. We found evidence of associations with RCC for four herbicides (2,4,5-T, atrazine, cyanazine, and paraquat) and two insecticides (chlorpyrifos and chlordane). Our findings provide insights into specific chemicals that may influence RCC risk among pesticide applicators. Confirmation of these findings and investigations of the biologic plausibility and potential mechanisms underlying the observed associations are warranted. https://doi.org/10.1289/EHP6334.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.