Evidence map›Paper›PMID 32691952›Full record

ArticleAdvanced healthcare materials2021

Magnetic Resonance Guided Navigation of Untethered Microgrippers.

Arijit Ghosh, Yizhang Liu, Dmitri Artemov, David H Gracias

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Mucosa-interfacing electronics.Nature reviews. Materials · 2022
    Review
  12. Hydrogel-Based Stimuli-Responsive Micromotors for Biomedicine.Cyborg and bionic systems (Washington, D.C.) · 2022
    Review
  13. Wireless MRI-Powered Reversible Orientation-Locking Capsule Robot.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  14. Medical Micro/Nanorobots in Precision Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Arijit GhoshChemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0003-3449-2317
Yizhang LiuChemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Dmitri ArtemovDepartment of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, MD, 21287, USA.
David H GraciasChemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0003-2735-4725

Funding

Tissue biopsying with wireless microgrippers within gastrointestinal tractR01EB017742 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI David H Gracias, Florin Selaru · 2014 to 2026
$6.6M
NIBIB NIH HHS R01 EB017742
6 · The paper itself

Abstract

Microsurgical tools offer a path to less invasive clinical procedures with improved access, reduced trauma, and better recovery outcomes. There are a variety of rigid and flexible endoscopic devices that have significantly advanced diagnostics and microsurgery. However, they rely on wires or tethers for guidance and operation of small end-effector tools. While untethered physiologically responsive microgrippers have been previously shown to excise tissue from deep gastrointestinal locations in animal models, there are challenges associated with guiding them along paths and moving them to specific locations. In this communication, the magnetic dipole moment of untethered thermally responsive grippers is optimized for efficient coupling to external magnetic resonance (MR) fields. Gripper encapsulation in a millimeter sized wax pellet reduces the friction with the surrounding tissue and MR Navigation (MRN) of a 700 µm sized microgripper is realized within narrow channels in tissue phantoms and in an ex vivo porcine esophagus. The results show convincing proof-of-concept evidence that it is possible to sequentially image, move, and guide a submillimeter functional microsurgical tool in tissue conduits using a commercial preclinical MR system, and when combined with prior demonstrations of physiologically responsive in vivo biopsy are an important step towards the clinical translation of untethered microtools.

Indexed as

RoboticsAnimalsMagnetic FieldsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMagneticsSwinemicroroboticsmicrosurgeryminimally invasive surgeryshape changing robots

Identifiers

PMID32691952
PMCPMC7854825

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.