Evidence map›Paper›PMID 32691881›Full record

SynthesisJournal of medical virology2021

Proportion of asymptomatic coronavirus disease 2019: A systematic review and meta-analysis.

Jingjing He, Yifei Guo, Richeng Mao, Jiming Zhang

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 228 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
228citing papers in PubMed, 15 pooled it
9.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

228 citing papers in PubMed, 15 syntheses or guidelines pooled it, 427 citations in OpenAlex.

  1. Long-Term Consequences of Asymptomatic SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023
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  13. Asymptomatic SARS-CoV-2 infection: A systematic review and meta-analysis.Proceedings of the National Academy of Sciences of the United States of America · 2021
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168 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jingjing HeDepartment of Infection Disease, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0003-0322-4846
Yifei GuoDepartment of Infection Disease, Huashan Hospital, Fudan University, Shanghai, China.
Richeng MaoDepartment of Infection Disease, Huashan Hospital, Fudan University, Shanghai, China.
Jiming ZhangDepartment of Infection Disease, Huashan Hospital, Fudan University, Shanghai, China.
Fudan University · CN

Funding

National Natural Science Foundation of China 81670528National Natural Science Foundation of China 81672009National Natural Science Foundation of China and 81871640Shanghai Pujiang Program 17PJD005
6 · The paper itself

Abstract

We aim to systematically review the characteristics of asymptomatic infection in the coronavirus disease 2019 (COVID-19). PubMed and EMBASE were electronically searched to identify original studies containing the rate of asymptomatic infection in COVID-19 patients before 20 May 2020. Then mate-analysis was conducted using R version 3.6.2. A total of 50 155 patients from 41 studies with confirmed COVID-19 were included. The pooled percentage of asymptomatic infection is 15.6% (95% CI, 10.1%-23.0%). Ten included studies contain the number of presymptomatic patients, who were asymptomatic at screening point and developed symptoms during follow-up. The pooled percentage of presymptomatic infection among 180 initially asymptomatic patients is 48.9% (95% CI, 31.6%-66.2%). The pooled proportion of asymptomatic infection among 1152 COVID-19 children from 11 studies is 27.7% (95% CI, 16.4%-42.7%), which is much higher than patients from all aged groups. Abnormal CT features are common in asymptomatic COVID-19 infection. For 36 patients from 4 studies that CT results were available, 15 (41.7%) patients had bilateral involvement and 14 (38.9%) had unilateral involvement in CT results. Reduced white blood cell count, increased lactate dehydrogenase, and increased C-reactive protein were also recorded. About 15.6% of confirmed COVID-19 patients are asymptomatic. Nearly half of the patients with no symptoms at detection time will develop symptoms later. Children are likely to have a higher proportion of asymptomatic infection than adults. Asymptomatic COVID-19 patients could have abnormal laboratory and radiational manifestations, which can be used as screening strategies to identify asymptomatic infection.

Indexed as

Asymptomatic InfectionsBiomarkersChinaCOVID-19C-Reactive ProteinFemaleHumansLeukocyte CountL-Lactate DehydrogenaseMaleReal-Time Polymerase Chain ReactionSARS-CoV-2Tomography, X-Ray ComputedBiomarkersC-Reactive ProteinL-Lactate Dehydrogenaseasymptomatic infectionchildren coronavirus disease 2019Coronavirus disease 2019COVID-19presymptomatic infectionSARS-CoV-2

Identifiers

PMID32691881
PMCPMC7404334
OpenAlexW3044331089

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.