ArticleeLife2020
A taxonomy of seizure dynamotypes.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed.
- From Computational Models to Clinical Decision-Making in Epilepsy: Bridging the Gap Between Theory and Practice.Brain topography · 2026Review
- Biophysically inspired mean-field model of neuronal populations driven by ion-exchange mechanisms.eLife · 2026Article
- Seizure recruitment properties are dependent upon dynamotype: A modeling study.PLoS computational biology · 2026Article
- A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- The seizure embedding map: a spatio-temporal transformer for comparing patients by ictal intracranial EEG features at scale.Journal of neural engineering · 2026Article
- Article
- Structural Eigenmodes of the Brain to Improve the Source Localization of EEG: Application to Epileptiform Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- Computational modeling of seizure reconstruction and attenuation via model reference control.Scientific reports · 2026Article
- White matter signals reflect information transmission between brain regions during seizures.Brain : a journal of neurology · 2026Article
- Toward Unified Biomarkers for Focal Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Data driven multiscale modelling of paroxysmal brain transitions using DC-coupled electrophysiological data.PloS one · 2026Article
- High-resolution Bayesian Virtual Epileptic Patient using neural field models.Network neuroscience (Cambridge, Mass.) · 2026Article
- States of dynamic connectivity flow in temporal multiplex networks: A case study in human epilepsy and postictal aphasia.Network neuroscience (Cambridge, Mass.) · 2026Article
- Nonlinear dynamics and multiscale mechanisms of deep brain stimulation.Frontiers in neuroscience · 2026Review
- Modelling dysfunction-specific interventions for seizure termination in epilepsy.NPJ systems biology and applications · 2025Article
- Article
- The Seizure Embedding Map: A Spatio-Temporal Transformer for Comparing Patients by Ictal Intracranial EEG Features at Scale.medRxiv : the preprint server for health sciences · 2025Article
- Article
- H- and m-channel overexpression promotes seizure-like events by impairing the ability of inhibitory neurons to process correlated inputs.PLoS computational biology · 2025Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Seizures are a disruption of normal brain activity present across a vast range of species and conditions. We introduce an organizing principle that leads to the first objective Taxonomy of Seizure Dynamics (TSD) based on bifurcation theory. The 'dynamotype' of a seizure is the dynamic composition that defines its observable characteristics, including how it starts, evolves and ends. Analyzing over 2000 focal-onset seizures from multiple centers, we find evidence of all 16 dynamotypes predicted in TSD. We demonstrate that patients' dynamotypes evolve during their lifetime and display complex but systematic variations including hierarchy (certain types are more common), non-bijectivity (a patient may display multiple types) and pairing preference (multiple types may occur during one seizure). TSD provides a way to stratify patients in complement to present clinical classifications, a language to describe the most critical features of seizure dynamics, and a framework to guide future research focused on dynamical properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.