Evidence map›Paper›PMID 32691653›Full record

ArticleJournal of the American Heart Association2020

Association Between the Gut Microbiota and Blood Pressure in a Population Cohort of 6953 Individuals.

Joonatan Palmu, Aaro Salosensaari, Aki S Havulinna, Susan Cheng, Michael Inouye, Mohit Jain, Rodolfo A Salido, Karenina Sanders, Caitriona Brennan, Gregory C Humphrey and 8 more

2 registry-linked trialsAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 79 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05194033 nacompletednot on this mapstarted 2022, after this paper: background citation

Efficacy and Safety of Oral Lactobacillus Plantarum GUANKE (CGMCC NO.21720) in Enhancement of Antibody Level After SARS-CoV-2 Vaccination: A Prospective, Randomized, Double-blind, Placebo-Controlled Trial (Trial 1)

TypeinterventionalSponsorPeking UniversityRan2022 to 2022Enrolled31ConditionsSARS-CoV-2ArmsProbiotics daily, Placebo daily
NCT05195047 nacompletednot on this mapstarted 2022, after this paper: background citation

Efficacy and Safety of Oral Lactobacillus Plantarum GUANKE (CGMCC NO.21720) in Enhancement of Antibody Level After SARS-CoV-2 Vaccination: A Prospective, Randomized, Double-blind, Placebo-Controlled Trial (Trial 2)

TypeinterventionalSponsorPeking UniversityRan2022 to 2022Enrolled44ConditionsSARS-CoV-2Arms1 week placebo(Week 1), 1 week of probiotics(Week 1), 1 week placebo(Week 2), 1 week of probiotics(Week 2), 1 week placebo(Week 3)
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Targeting Gut Microbiota to Treat Hypertension: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  5. Pooled it
  6. Trial
  7. Review
  8. Review
  9. Article
  10. Article
  11. Gut microbiota-derived polyamine pathways associated with mean blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  12. Nutrients · 2026
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Joonatan PalmuDepartment of Medicine Turku University Hospital and University of Turku Finland.
Aaro SalosensaariDepartment of Medicine Turku University Hospital and University of Turku Finland.
Aki S HavulinnaDepartment of Public Health Solutions Finnish Institute for Health and Welfare Helsinki Finland.
Susan ChengDivision of Cardiology Brigham and Women's Hospital Boston MA.
Michael InouyeCambridge Baker Systems Genomics Initiative Baker Heart and Diabetes Institute Melbourne Australia.
Mohit JainDepartments of Medicine and Pharmacology University of California, San Diego San Diego CA.
Rodolfo A SalidoDepartment of Pediatrics University of California, San Diego CA.
Karenina SandersDepartment of Pediatrics University of California, San Diego CA.
Caitriona BrennanDepartment of Pediatrics University of California, San Diego CA.
Gregory C HumphreyDepartment of Pediatrics University of California, San Diego CA.
Jon G SandersDepartment of Pediatrics University of California, San Diego CA.
Erkki VartiainenDepartment of Public Health Solutions Finnish Institute for Health and Welfare Helsinki Finland.
Tiina LaatikainenDepartment of Public Health Solutions Finnish Institute for Health and Welfare Helsinki Finland.
Pekka JousilahtiDepartment of Public Health Solutions Finnish Institute for Health and Welfare Helsinki Finland.
Veikko SalomaaDepartment of Public Health Solutions Finnish Institute for Health and Welfare Helsinki Finland.
Rob KnightDepartment of Pediatrics University of California, San Diego CA.
Leo LahtiDepartment of Future Technologies University of Turku Finland.
Teemu J NiiranenDepartment of Medicine Turku University Hospital and University of Turku Finland.

Funding

Cardiac microstructure and the immune-inflammatory response to SARS-CoV-2R01HL131532 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN, LI, DEBIAO · 2016 to 2025
$6.6M
Mapping the Plasma Exposome and its Association with Human Cardiovascular DiseaseR01ES027595 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAIN, MOHIT · 2017 to 2021
$3.3M
Mediators of Systemic Inflammation and Heart Failure Risk in the CommunityR01HL143227 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN · 2019 to 2022
$3.3M
Ventricular-vascular coupling in the elderly: lifecourse determinants, trajectories, and prognostic significanceR01HL142983 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHENG, SUSAN, MITCHELL, GARY FRANK · 2019 to 2022
$3.2M
Inflammatory Mediators, Cardiovascular Health, and Longevity in WomenR01HL134168 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN · 2016 to 2019
$1.6M
RapidFire mass spectrometry systemS10OD020025 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAIN, MOHIT · 2015 to 2015
$600k
NHLBI NIH HHS R01 HL131532NHLBI NIH HHS R01 HL134168NHLBI NIH HHS R01 HL142983NHLBI NIH HHS R01 HL143227NIEHS NIH HHS R01 ES027595NIH HHS S10 OD020025
6 · The paper itself

Abstract

Background Several small-scale animal studies have suggested that gut microbiota and blood pressure (BP) are linked. However, results from human studies remain scarce and conflicting. We wanted to elucidate the multivariable-adjusted association between gut metagenome and BP in a large, representative, well-phenotyped population sample. We performed a focused analysis to examine the previously reported inverse associations between sodium intake and

Indexed as

Blood PressureGastrointestinal MicrobiomeLactobacillusAdultAgedCohort StudiesFemaleHumansHypertensionMaleMetagenomeMiddle AgedSodium, DietarySodium, Dietaryblood pressuregastrointestinal microbiotahypertensionLactobacillussalt intake

Identifiers

PMID32691653
PMCPMC7792269

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.