ArticleAmerican journal of physiology. Endocrinology and metabolism2020
The contribution of the mouse tail to thermoregulation is modest.
Article in American journal of physiology. Endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Don't Sweat It: Cannabinoid CB1 Receptors Reduce Sweating in a Mouse Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Neither rats nor mice have a broad thermoneutral zone: implications for physiological studies.Communications biology · 2026Article
- The neural thermostat malfunction: revisiting heatstroke through the lens of warm-sensitive neuron dysregulation.Frontiers in cellular neuroscience · 2026Review
- Extreme temperature exposure induces lung-gut dysbiosis in healthy mice.Current research in microbial sciences · 2026Article
- Arteries are finely tuned thermosensors regulating myogenic tone and blood flow.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Limited evidence that body size shrinking and shape-shifting alleviate thermoregulatory pressures in a warmer world.Communications biology · 2025Article
- HOUSING TEMPERATURE ALTERS BURN-INDUCED HYPERMETABOLISM IN MICE.Shock (Augusta, Ga.) · 2025Article
- Aging is associated with impaired triggering of TRPV3-mediated cutaneous vasodilation: a crucial process for local heat exposure.GeroScience · 2024Article
- Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression, and impaired satellite cell function in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Delayed metabolic disturbances in the myocardium after exertional heat stroke: contrasting effects of exertion and thermal load.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- A mast cell-thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis.Science immunology · 2023Article
- Rodent Thermoregulation: Considerations for Tail-Cuff Blood Pressure Measurements.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Effect of Different Ambient Temperatures on Reproductive Outcome and Stress Level of Lactating Females in Two Mouse Strains.Animals : an open access journal from MDPI · 2022Article
- Article
- Role of TRPM8 in switching between fever and hypothermia in adult mice during endotoxin-induced inflammation.Brain, behavior, & immunity - health · 2021Article
- The Hypothermic Effect of Hydrogen Sulfide Is Mediated by the Transient Receptor Potential Ankyrin-1 Channel in Mice.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways.Cell metabolism · 2021Article
- A Neuroscientist's Guide to the Vole.Current protocols · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Understanding mouse thermal physiology informs the usefulness of mice as models of human disease. It is widely assumed that the mouse tail contributes greatly to heat loss (as it does in rat), but this has not been quantitated. We studied C57BL/6J mice after tail amputation. Tailless mice housed at 22°C did not differ from littermate controls in body weight, lean or fat content, or energy expenditure. With acute changes in ambient temperature from 19 to 39°C, tailless and control mice demonstrated similar body temperatures (Tb), metabolic rates, and heat conductances and no difference in thermoneutral point. Treatment with prazosin, an α1-adrenergic antagonist and vasodilator, increased tail temperature in control mice by up to 4.8 ± 0.8°C. Comparing prazosin treatment in tailless and control mice suggested that the tail's contribution to total heat loss was a nonsignificant 3.4%. Major heat stress produced by treatment at 30°C with CL316243, a β3-adrenergic agonist, increased metabolic rate and Tb and, at a matched increase in metabolic rate, the tailless mice showed a 0.72 ± 0.14°C greater Tb increase and 7.6% lower whole body heat conductance. Thus, the mouse tail is a useful biomarker of vasodilation and thermoregulation, but in our experiments contributes only 5-8% of whole body heat dissipation, less than the 17% reported for rat. Heat dissipation through the tail is important under extreme scenarios such as pharmacological activation of brown adipose tissue; however, non-tail contributions to heat loss may have been underestimated in the mouse.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.