ArticleJournal of cardiovascular pharmacology and therapeutics2020
The JUUL E-Cigarette Elevates the Risk of Thrombosis and Potentiates Platelet Activation.
Article in Journal of cardiovascular pharmacology and therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Findings on e-cigarette flavors and their implications for human health: a systematic review.Frontiers in public health · 2026Pooled it
- Tobacco and marijuana induce adverse effects on cardiac function and platelet activity and reduce tissue preservation following myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2026Article
- Risk Modulation by Electronic Cigarette Consumption in Cardiovascular Disease and Its Relevance in Cardiac Surgery-A Narrative Review.Journal of cardiovascular development and disease · 2026Review
- The Prothrombotic Phenotype of Thirdhand Electronic Cigarette Exposure is Sex Independent and Involves Systemic Mediated Effects on Platelet Function: Evidence from a Mouse Model.Cardiovascular toxicology · 2026Article
- The Impact of Maternal/In Utero Exposure of Novel Tobacco Products on the Offspring Cardiovascular Health.Cardiovascular toxicology · 2025Review
- A comprehensive assessment of smokeless tobacco (Shammah) extract: unraveling the effects on hematological parameters, antioxidant defense mechanisms, and organ health in rats.Journal of molecular histology · 2025Article
- The Hidden Dangers: E-Cigarettes, Heated Tobacco, and Their Impact on Oxidative Stress and Atherosclerosis-A Systematic Review and Narrative Synthesis of the Evidence.Antioxidants (Basel, Switzerland) · 2024Review
- Sex-Dependent Occlusive Cardiovascular Disease Effects of Short-Term Thirdhand Smoke Exposure.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Investigation of the impact of thirdhand e-cigarette exposure on platelet function: A pre-clinical study.Tobacco induced diseases · 2024Article
- Nicotine and Cardiovascular Health: When Poison is Addictive - a WHF Policy Brief.Global heart · 2024Article
- Endothelial-derived extracellular vesicles associated with electronic cigarette use impair cerebral microvascular cell function.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Electronic Nicotine Delivery Systems and Cardiovascular/Cardiometabolic Health.Circulation research · 2023Review
- Short-term exposure of female BALB/cJ mice to e-cigarette aerosol promotes neutrophil recruitment and enhances neutrophil-platelet aggregation in pulmonary microvasculature.Journal of toxicology and environmental health. Part A · 2023Article
- Exposure, Retention, Exhalation, Symptoms, and Environmental Accumulation of Chemicals During JUUL Vaping.Chemical research in toxicology · 2023Article
- Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome.Fluids and barriers of the CNS · 2022Article
- Comparable Impairment of Vascular Endothelial Function by a Wide Range of Electronic Nicotine Delivery Devices.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Article
- Article
- The effect of emerging tobacco related products and their toxic constituents on thrombosis.Life sciences · 2022Review
- E-Cigarette Toxicology.Annual review of pharmacology and toxicology · 2022Review
- The association between electronic cigarettes, sleep duration, and the adverse cardiovascular outcomes: Findings from behavioral risk factor surveillance system, 2020.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundSmoking is the main preventable cause of death in the United States and worldwide and is associated with serious cardiovascular health consequences, including thrombotic diseases. Recently, electronic cigarettes (e-cigarettes) and, in particular JUUL, have attained wide popularity among smokers, nonsmokers, pregnant females, and even the youth, which is alarming. Interestingly, there is/are no information/studies regarding the effect of JUUL on cardiovascular diseases, specifically in the context of modulation of platelet activation. Thus, it is important to discern the cardiovascular disease health risks associated with JUUL. METHODS AND
resultsWe used a passive e-vape vapor inhalation system where C57BL/6J mice (10-12 weeks old) were exposed to JUUL e-cigarette vape. Menthol flavored JUUL pods containing 5% nicotine by weight were used as the e-liquid. Mice were exposed to a total of 70 puffs daily for 2 weeks; 3-second puff duration, and 25-second puff interval. The effects of JUUL relative to clean air were analyzed, on mouse platelet function in vitro (eg, aggregation) and in vivo (eg, FeCl
conclusionOur findings document-for the first time-that short-term exposure to the JUUL e-cigarette increases the risk of thrombotic events, in part by modulating platelet function, such as aggregation and secretion, in mice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.