ArticlePediatric diabetes2020
Increased tissue factor activity promotes thrombin generation at type 1 diabetes onset in children.
Article in Pediatric diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Hemostatic Effects of Exercise-related Hypoglycemia in Male Persons With Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2024Trial
- Acetylsalicylic acid modulates progression of endogenous thrombin potential in high-risk pregnancies.PloS one · 2026Article
- Deep Vein Thrombosis as the Presenting Sign in an Adolescent With New-Onset Type 2 Diabetes.JCEM case reports · 2024Article
- Only Subclinical Alterations in the Haemostatic System of People with Diabetes after COVID-19 Vaccination.Viruses · 2022Article
- Article
- Increased tissue factor activity promotes thrombin generation at type 1 diabetes onset in children.Pediatric diabetes · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn type 1 diabetes (T1D), a prothrombotic status due to elevated coagulation factors coincides with metabolic derailment. In a previous study, we discovered altered thrombin generation profiles in children with T1D. These alterations are potentially most pronounced at T1D onset and ameliorated after insulin treatment. We tested this hypothesis in a longitudinal study, measuring thrombin generation together with coagulation parameters in children at T1D onset and during follow-up. MATERIALS AND
methodsTwenty-three children (12 female, age: 9.4 [2.7-17.3] years; median [range]) were tested at T1D onset and after long-term insulin treatment. Thrombin generation was measured using calibrated automated thrombography. Tissue factor (TF) activity and tissue factor pathway inhibitor (TFPI) activity were measured using enzyme-linked immunosorbent assay (ELISA).
resultsA procoagulant shift was observed in thrombin generation traces at T1D onset compared to follow-up (time to peak: 5.67 [4.11-7.67] min vs 6.39 [4.89-10.44] min, P < .001). These alterations at T1D onset coincided with increased TF activity (5.18 [0.01-12.97] pmol/L vs 2.67 [0.04-10.41] pmol/L, P < .05) and increased TFPI activity (0.051 [0.038-0.074] U/mL vs 0.035 [0.026-0.056] U/mL, P < .05).
conclusionThe procoagulant shift in thrombin generation at T1D onset is a result of increased TF activity, but this effect is partially counterbalanced by increased TFPI levels. Elevated TF and TFPI levels hint to a fragile hemostatic balance at the endothelial lining of blood vessels. Additional prothrombotic stimuli may tip over this balance explaining the increased thrombotic risk of children with T1D.
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