Evidence map›Paper›PMID 32691305›Full record

ReviewIrish journal of medical science2021

Thromboembolic complications and cardiovascular events associated with celiac disease.

Fotios S Fousekis, Eleni T Beka, Ioannis V Mitselos, Haralampos Milionis, Dimitrios K Christodoulou

Abstract readReview
PubMed Publisher
In one paragraph

Review in Irish journal of medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Extra-digestive manifestations of celiac disease.Medicine and pharmacy reports · 2024
    Article
  7. Review
  8. Article
  9. Deep Vein Thrombosis Revealing A "Silent" Coeliac Disease.European journal of case reports in internal medicine · 2023
    Article
  10. Who to screen and how to screen for celiac disease.World journal of gastroenterology · 2022
    Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fotios S FousekisDepartment of Gastroenterology and Hepatology, School of Health Sciences, Faculty of Medicine, University Hospital of Ioannina, University of Ioannina, POBox 1186, 45110, Ioannina, Greece.
Eleni T BekaDepartment of Gastroenterology and Hepatology, School of Health Sciences, Faculty of Medicine, University Hospital of Ioannina, University of Ioannina, POBox 1186, 45110, Ioannina, Greece.
Ioannis V MitselosDepartment of Gastroenterology and Hepatology, School of Health Sciences, Faculty of Medicine, University Hospital of Ioannina, University of Ioannina, POBox 1186, 45110, Ioannina, Greece.
Haralampos Milionis1st Department of Internal Medicine, School of Health Sciences, Faculty of Medicine, University Hospital of Ioannina, University of Ioannina, Ioannina, Greece.
Dimitrios K ChristodoulouDepartment of Gastroenterology and Hepatology, School of Health Sciences, Faculty of Medicine, University Hospital of Ioannina, University of Ioannina, POBox 1186, 45110, Ioannina, Greece. dchristodoulou@gmail.com.ORCID http://orcid.org/0000-0001-9694-1160

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Celiac disease (CD) is a chronic intestinal immune-mediated disease occurring in genetically susceptible individuals who are exposed to gluten. Although it primarily affects the small intestine, CD has been associated with a wide spectrum of extraintestinal manifestations, including thromboembolism and cardiovascular events. The risk of ischemic stroke, myocardial infarction, and thromboembolism, such as deep vein thrombosis and pulmonary embolism, is higher in patients with CD, while there is accumulating evidence that gluten-free diet in CD patients decreases the risk of these complications. The pathogenetic mechanism of increasing hypercoagulability in CD is multifactorial and involves hyperhomocysteinemia due to malabsorption of vitamins B12, B6, and folic acid; endothelial dysfunction; acceleration of atherosclerosis; chronic inflammation; thrombocytosis; and thrombophilia. Therefore, in cases of thromboembolic complications and cardiovascular disease of obscure etiology, clinicians' awareness of possible celiac disease is warranted.

Indexed as

Cardiovascular DiseasesCeliac DiseaseFemaleHumansMaleThromboembolismAtherosclerosisCeliac diseaseExtra-intestinal manifestationsHypercoagulabilityThromboembolism

Identifiers

PMID32691305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.