Evidence map›Paper›PMID 32691303›Full record

ReviewMolecular neurobiology2020

A Review of Exercise-Induced Neuroplasticity in Ischemic Stroke: Pathology and Mechanisms.

Ying Xing, Yulong Bai

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 97 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 6 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05405140 nacompletednot on this mapstarted 2022, after this paper: background citation

Multiphasic Neuroplasticity Based Training Protocol With Shock Wave Therapy For Post Stroke Spasticity

TypeinterventionalSponsorRiphah International UniversityRan2022 to 2023Enrolled32ConditionsStroke, Spasticity, MuscleArmsShock wave therapy with multiphasic neuroplasticity based training protocol, Conventional physical therapy
NCT06726941 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Exercise on Neuroplasticity-Related Gene Expression and Histone Modifications in Patients With Hemiplegia

TypeinterventionalSponsorAfyonkarahisar Health Sciences UniversityRan2024 to 2026Enrolled48ConditionsIschemic Stroke, Acute, Acute HemiparesisArmsPhysiotherapy and Rehabilitation Practices
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 6 syntheses or guidelines pooled it, 153 citations in OpenAlex.

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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ying XingDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Jing'an District, Shanghai, 200040, China.
Yulong BaiDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Jing'an District, Shanghai, 200040, China. dr_baiyl@fudan.edu.cn.ORCID http://orcid.org/0000-0003-0461-1506
Fudan University · CN

Funding

National Natural Science Foundation of China 81871841
6 · The paper itself

Abstract

After ischemic stroke, survivors experience motor dysfunction and deterioration of memory and cognition. These symptoms are associated with the disruption of normal neuronal function, i.e., the secretion of neurotrophic factors, interhemispheric connections, and synaptic activity, and hence the disruption of the normal neural circuit. Exercise is considered an effective and feasible rehabilitation strategy for improving cognitive and motor recovery following ischemic stroke through the facilitation of neuroplasticity. In this review, our aim was to discuss the mechanisms by which exercise-induced neuroplasticity improves motor function and cognitive ability after ischemic stroke. The associated mechanisms include increases in neurotrophins, improvements in synaptic structure and function, the enhancement of interhemispheric connections, the promotion of neural regeneration, the acceleration of neural function reorganization, and the facilitation of compensation beyond the infarcted tissue. We also discuss some common exercise strategies and a novel exercise therapy, robot-assisted movement, which might be widely applied in the clinic to help stroke patients in the future.

Indexed as

ExerciseHumansIschemic StrokeNerve RegenerationNerve TissueNeuronal PlasticityRecovery of FunctionAMPA receptorsExerciseIschemic strokeNeuroplasticityNeurotrophinsRegeneration

Identifiers

PMID32691303
OpenAlexW3045054335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.